نتایج جستجو برای: stearoyl

تعداد نتایج: 1538  

Journal: :Atlas of Genetics and Cytogenetics in Oncology and Haematology 2017

Journal: :Journal of Biological Chemistry 2006

2013
Christina A. von Roemeling Laura A. Marlow Johnny J. Wei Simon J. Cooper Thomas R. Caulfield Kevin Wu Winston W. Tan Han W. Tun John A. Copland

Purpose:We set out to identify Stearoyl-CoA desaturase 1 (SCD1) as a novelmolecular target in clear cell renal cell carcinoma (ccRCC) and examine its role in tumor cell growth and viability in vitro and in vivo independently as well as in combination with current U.S. Food andDrug Administration (FDA)-approved

2011
Hyun Joo Do Hye Kyung Chung Jiyoung Moon Min-Jeong Shin

In the present study, we evaluated the relationships of estimated desaturase activities with cardiometabolic risk factors including abdominal obesity, atherogenic lipoprotein phenotype and inflammation in Koreans. Ninety-three healthy volunteers participated in this cross-sectional study. LDL particle size was determined using gradient gel electrophoresis and inflammatory markers including C-re...

Journal: :American Journal of Physiology-Endocrinology and Metabolism 2009

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2013
Janet Y Leung William Y Kim

There is a need for the discovery of novel therapeutic strategies to effectively treat advanced clear cell renal cell carcinoma (ccRCC). Inhibition of stearoyl-coA desaturase 1 (SCD1) in ccRCC reveals antitumor activity, independently and in synergy with mTOR inhibition. SCD1 may be a potential novel therapeutic target in treating ccRCC.

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