OBJECTIVE To study the association of long-term statin use and the risk of low-energy hip fractures in middle-aged and elderly women. DESIGN A register-based cohort study. SETTING Finland. PARTICIPANTS Women aged 45-75 years initiating statin therapy between 1996 and 2001 with adherence to statins ≥ 80% during the subsequent five years (n = 40,254), a respective cohort initiating hyperten...

While statins were developed as drugs to suppress cholesterol synthesis, they also prevent vascular diseases off-target effects. Numerous experimental and clinical studies have proven that could be beneficial for reducing ictogenesis epileptogenesis. We aimed summarize elaborate on up-to-date evidence of the role in epilepsy consider mechanisms responsible their Key words: Statin; Epileptogenes...

The American College of Cardiology and the American Heart Association (ACC/AHA) 2013 joint guidelines for the treatment of hypercholesterolemia expand the indications for statin therapy. This study was performed to estimate the numbers of diabetic patients indicated for statin therapy according to the Third Adult Treatment Panel (ATP-III) of the National Cholesterol Education Program guidelines...

BACKGROUND We investigated associations between statin use begun before prostate cancer (PCa) diagnosis and PCa recurrence/progression and PCa-specific mortality (PCSM) in a prospective, population-based cohort study. METHODS The analysis included 1,001 PCa patients diagnosed in 2002-2005 in King County, Washington. Statin use was assessed at the time of diagnosis using a detailed in-person i...

PURPOSE OF REVIEW Despite advances in medical therapy and percutaneous revascularization, patients with acute coronary syndrome face a high risk of early, recurrent cardiovascular events. Interventions targeting atherogenic lipoproteins may favorably modify this risk. RECENT FINDINGS Two randomized clinical trials, MIRACL and PROVE-IT, demonstrated efficacy of early, intensive statin therapy ...

BACKGROUND statin drugs may induce skeletal myopathy, but might also have the potential to improve rehabilitation outcomes by improving sarcopenia or by preventing intercurrent illness. We examined the association between statin use and functional outcomes in the rehabilitation of older people. METHODS retrospective cohort study using routinely collected clinical data. Admissions to Royal Vic...

Lipid-lowering therapy with statins reduces the risk of cardiovascular events in patients with coronary artery disease. Recent in vitro and in vivo studies demonstrated a low-density lipoprotein-independent action of this class of drugs, which appears to modulate endothelial function, inflammation, and thrombosis. Randomized studies showed a beneficial effect of short-term statin pretreatment i...

The Ebola viral disease is the serious infection that becomes the global health concern. The recent outbreak in Africa leads several attempts to develop new treatment. Several drugs are proposed as new therapeutic agent. Statins has been recently proposed as new immune modulating drugs that can be useful for management of Ebola viral disease [1 -2]. In general, statin is the specific group of d...