The goal of this study was to determine the effects of the L-type calcium channel blockers verapamil and diltiazem on the currents of voltage-gated potassium channel (fKv1.4ΔN), an N-terminal-deleted mutant of the ferret Kv1.4 potassium channel. Measurements were made using a two electrode voltage clamp technique with channels expressed stably in Xenopus oocytes. The fKv1.4ΔN currents displayed...

The goal of this study was to determine the effects of the L-type calcium channel blockers verapamil and diltiazem on the currents of voltage-gated potassium channel (fKv1.4ΔN), an N-terminal-deleted mutant of the ferret Kv1.4 potassium channel. Measurements were made using a two electrode voltage clamp technique with channels expressed stably in Xenopus oocytes. The fKv1.4ΔN currents displayed...

In this paper, we address the design of parameter-dependent mixed filters for output estimation of linear parameter-varying (LPV) plants that include a time-varying delay. We investigate the conditions to satisfy asymptotic stability, and and performance requirements in terms of linear matrix inequalities (LMIs). Our synthesis conditions, that provide mixed filters, are dependent linearly on th...

In this paper, a general elastoplastic-damage constitutive model considering the effect of strain rate has been developed. The derivation of this model has been cast into the irreversible thermodynamics with internal variables within the fundamentals of Continuum Damage Mechanics (CDM). The rate effect has been involved as an additional term into the plastic yield surface (dynamic plastic yield...

the capability of sand constitutive models is remarkably improved by taking into account the effect of soil state in their formulations. in this study, it has been shown that considering the effect of soil state leads to better simulation of soil instability of shear banding type. to this aim, constitutive equations of a state dependent sand model are explained first. consequently, the general ...