INTRODUCTION Recent accumulating evidence indicates a crucial involvement of macrophage lineage in the pathogenesis of systemic sclerosis (SSc). To analyze the assembly of the monocyte/macrophage population, we evaluated the expression of CD163 and CD204 and various activated macrophage markers, in the inflammatory cells of the skin and in the peripheral blood mononuclear cells (PBMCs) derived ...

OBJECTIVES To determine how sensitively SSc-associated ANAs are detected by a standard identification algorithm compared with an extensive panel of ANA identification assays, and to assess the distribution of SSc-associated ANAs and SSc organ system involvement in patients without skin involvement (limited SSc). METHODS Serum samples from 145 consecutive monocentric SSc patients fulfilling Le...

BACKGROUND Systemic sclerosis (SSc) is characterized by endothelial cell (EC) apoptosis, impaired angiogenesis and peripheral microvasculopathy. Soluble α-Klotho (sKl) is a pleiotropic molecule with multiple effects on ECs, including antioxidant and vasculoprotective activities. On the EC surface, sKl interacts with vascular endothelial growth factor (VEGF) receptor-2 (VEGFR-2) and transient re...

The creation of a gold standard corpus (GSC) is a very laborious and costly process. Silver standard corpus (SSC) annotation is a very recent direction of corpus development which relies on multiple systems instead of human annotators. In this paper, we investigate the practical usability of an SSC when a machine learning system is trained on it and tested on an unseen benchmark GSC. The main f...

Systemic sclerosis (SSc) is a multiorgan connective tissue disease characterized by autoantibody production and fibroproliferative stenosis of the microvasculature. The vascoluopathy associated with SSc is considered to be noninflammatory, yet frank vasculitis can complicate SSc, posing diagnostic and therapeutic challenges. Here, we have reviewed the literature for reports of small-, medium-, ...

BACKGROUND Patients with idiopathic interstitial pneumonias sometimes have a few features of connective tissue disease (CTD) and yet do not fulfil the diagnostic criteria for any specific CTD. OBJECTIVE This study was conducted to elucidate the characteristics, prognosis, and disease behavior in patients with interstitial lung disease (ILD) associated with systemic sclerosis (SSc)-related aut...

A technológiai fejlődéssel az élő munkát kiváltó alkalmazások, megoldások egyre elterjedtebbé válnak nemcsak iparban, hanem a szolgáltatások területén is. cikk nemzetközi szolgáltató központokra (SSC-k) fókuszálva elemzi robotizált folyamatautomatizálás (RPA) által kínálkozó lehetőségeket és azok munkaerőpiaci hatásait. Az elemzés tágabb környezetből indul, de elsődleges célja magyar szektor he...

The subscapularis (SSC) muscle is the most powerful of the rotator cuff muscles, and plays an important role in shoulder motion and stabilization. SSC tendon tear is quite uncommon, compared to the supraspinatus (SSP) tendon, and, most of the time, part of a large rupture of the rotator cuff. Various complementary imaging techniques can be used to obtain an accurate diagnosis of SSC tendon lesi...

OBJECTIVE To evaluate infant thermal balance and the physical environment in extremely preterm infants during skin-to-skin care (SSC). STUDY DESIGN Measurements were performed in 26 extremely preterm infants (gestational age 22-26 weeks; postnatal age, 2-9 days) during pretest (in incubator), test (during SSC), and posttest (in incubator) periods. Infants' skin temperature and body temperatur...