Patients with breast cancer and bone metastases often experience skeletal complications (skeletal-related events [SREs]: pathologic fracture, radiation to bone, surgery to bone or spinal cord compression). Prospective data on the health resource burden of SREs are needed for planning healthcare requirements and estimating the value of new treatments, but limited data are available. This prospec...

The aim of the bone metastases (BM) treatment is to prevent the occurrence of skeletal-related events (SREs). In clinical, physicians could only predict the occurrence of SREs by subjective experience. Machine learning (ML) could be used as predictive models in the medical field. But there is no published research using ML to predict SREs in cancer patients with BM. The purpose of this study wa...

BACKGROUND The skeleton is one of the most frequent sites for metastases from non-small cell lung cancer (NSCLC), and skeletal-related events (SREs) can decrease quality of life (QOL). However, limited guidance exists regarding the diagnosis and treatment of bone metastases in patients with NSCLC. METHODS Data on the burden of skeletal morbidity and the diagnosis and treatment of bone metasta...

Egr-1, a mitogen-responsive transcription factor, is rapidly induced by v-Fps in the absence of protein synthesis. Thus, Egr-1 is a primary response to the protein-tyrosine kinase activity of v-Fps. To determine the v-Fps-responsive elements in the Egr-1 promoter, deletion mutants of the Egr-1 promoter were used in transient expression assays. A v-Fps expression vector was contransfected into N...

Strain engineering of nanomaterials, namely, designing, tuning, or controlling surface strains nanomaterials is an effective strategy to achieve outstanding performance in different for their various applications. This article summarizes recent progress and achievements the development strain-rich electrocatalysts (SREs) applications field electrochemical energy conversion technologies. It star...

Current scientific knowledge on the future response of the climate system to human-induced perturbations is comprehensively captured by various model intercomparison efforts. In the preparation of the Fourth Assessment Report (AR4) of the Intergovernmental Panel on Climate Change (IPCC), intercomparisons were organized for atmosphere-ocean general circulation models (AOGCMs) and carbon cycle mo...

Recent studies by the United Nations Environment Programme (UNEP) and the Intergovernmental Panel on Climate Change (IPCC) indicate that Vietnam is one of the countries most affected by climate change. The variability of climate in this region, characterized by large fluctuations in precipitation and temperature, has caused significant changes in surface water resources. This study aims to proj...

Forecasts of decadal climate change at subcontinental scales made by global climate models (GCMs) are currently too uncertain to be useful to policy makers. For example, the forecasts of global mean surface temperatures in the current Intergovernmental Panel on Climate Change (IPCC) Special Report on Emissions (SRES) A1B scenario show an agreement across 15 models of about ±0.75 K in warming of...

Perturbed physics experiments are among the most comprehensive ways to address uncertainty in climate change forecasts. In these experiments, parameters and parametrizations in atmosphere-ocean general circulation models are perturbed across ranges of uncertainty, and results are compared with observations. In this paper, we describe the largest perturbed physics climate experiment conducted to...