In our study we investigated the release mechanisms of coated oral dosage forms more deeply. The aim of the study was to monitor the buffer induced leaching out of water soluble compounds from Kollicoat SR films and to relate this process to the film properties and the release kinetics. Propranolol HCl tablets were coated with different amounts and ratios of polyvinyl acetate (Kollicoat SR) and...

The development and in vivo analytical performance of a nitric oxide (NO)-releasing amperometric oxygen sensor with greatly enhanced thromboresistivity are reported. Gas permeable coatings formulated with cross-linked silicone rubber (SR) containing NO-generating compounds (diazeniumdiolates) are shown to release NO for extended periods of time (> 20 h) while reducing platelet adhesion and acti...

Tremendous efforts to develop high-efficiency reduced-temperature (≤ 600°C) solid oxide fuel cells are motivated by their potentials for reduced materials cost, less engineering challenge, and better performance durability. A key obstacle to such fuel cells arises from sluggish oxygen reduction reaction kinetics on the cathodes. Here we reported that an oxide hybrid, featuring a nanoporous Sm(0...

This study investigates the influence of substrate (AISI M42 tool steel) bias voltage (from −30 to −80 V), on mechanical properties magnetron sputtered TiSiN coating derived from Ti and Si targets. Thermal stability, microstructure (crystallite size, microstrain, lattice constant), morphology (hardness, Young's modulus, residual stresses) properties, deposited coatings, were investigated with s...

This in vitro study performed elemental analysis of the ions absorbed into the salivary coat covering the surfaces of S-PRG resin blocks and assessed the adherence of Streptococcus sanguinis and Streptococcus mutans to these saliva-coated S-PRG resin blocks. Elemental analysis of ions absorbed into the salivary coat of resin blocks exposed to the saliva was performed using an inductive coupled ...

High resolution ESI mass spectrometry of the "22 kDa" nanocluster reveals the presence of a mixture containing Au103(SR)45, Au104(SR)45, Au104(SR)46, and Au105(SR)46 nanoclusters, where R = -CH2CH2Ph. MALDI TOF MS data confirm the purity of the sample and a UV-vis spectrum shows minor features. Au102(SC6H5COOH)44, whose XRD crystal structure was recently reported, is not observed. This is due t...

A new approach for SrBi2Nb2O9 (SBN) thin ®lms synthesis using aqueous solution was successfully experienced. The deposition solution was prepared from Sr±Bi±Nb mixed-citrate solution, requiring no special atmosphere and using common reagents. Films were deposited by dip coating onto Pt/Ti/SiO2/ Si(100) substrates and heat treated at temperatures ranging from 300 to 700 C. The process of formati...

The search for apatitic calcium phosphate coatings to improve implants osteointegration is, nowadays, preferentially focused in the obtaining of compositions closer to that of the inorganic phase of bone. Silicon and strontium are both present in trace concentrations in natural bone and have been demonstrated, by separate, to significantly improve osteoblastic response on calcium phosphate bioc...

An accurate computational strategy for studying the structural, redox and optical properties of thiolated gold nanoclusters (GNCs) using (Time-Dependent) Density Functional Theory is proposed. The influence of the pseudopotential/basis set, solvent description and the choice of the functional has been investigated to model the structural and electronic properties of the Au25(SR)18(-) system, wi...