Recently, squamous cell carcinoma of the head and neck chemoprevention research has made major advances with novel clinical trial designs suited for the purpose, use of biomarkers to identify high-risk patients, and the emergence of numerous molecularly targeted agents and natural dietary compounds. Among many natural compounds, green tea polyphenols, particularly (-)-epigallocatechin-3-gallate...

BACKGROUND Dynamic predictions on head and neck cancer survival could offer, besides improved patient counseling, insight into long-term effects of tumor- and patient-based characteristics on survival. Theoretically, there could be a certain time period after diagnosis after which the patient returns to a population risk on survival. METHODS In all, 7255 patients with a primary head and neck ...

A new antibody associated with squamous cell carcinoma, YM-Antibody, containing components of pI 5.95-6.10 fractions, was produced from cell cultures of squamous cell carcinoma of the larynx. To elucidate the immunological characteristics of YM-Antibody, it and 6 other commercially available antibodies were investigated immunohistochemically by applying them to squamous cell carcinomas and non-...

EDUCATIONAL OBJECTIVE At the conclusion of this presentation, the participants should be familiar with the clinical and pathologic features of collision tumors in the head and neck. OBJECTIVES Present a case of collision tumor of the head and neck consisting of metastatic squamous cell carcinoma and B-cell lymphoma. Review the literature on collision tumors of the head and neck. STUDY DESIG...

Numerous studies have investigated the risk of cancer associated with the polymorphism of p21 3' UTR (rs1059234 C > T), but results have been inconsistent. We performed this meta-analysis to drive a more precise estimation of the association between this polymorphism and risk of cancer. A comprehensive search was conducted to identify all case-control studies of the rs1059234 C > T polymorphism...

Head and neck cancer is the 5th most common cancer in the world with half a million new cases reported globally every year, 44,600 within the United States. Up to 40% of head and neck cancer patients will eventually die because of it. With half of patients having an advanced stage of disease upon initial diagnosis. Squamous cell carcinoma contributes to 95% of head and neck cancers. Squamous ce...

BACKGROUND Metallopanstimulin (MPS-1) is a ribosomal protein that is found in elevated amounts in the sera of patients with head and neck squamous cell carcinoma (HNSCC). We used a test, denoted MPS-H, which detects MPS-1 and MPS-1-like proteins, to determine the relationship between MPS-H serum levels and clinical status of patients with, or at risk for, HNSCC. PATIENTS AND METHODS A total o...

Radiotherapy is frequently employed for the treatment of head and neck squamous cell carcinoma. Among the side effects, xerostomia is one of the most important. With the objective of evaluating the role of radiotherapy in salivary flow, we performed three salivary sample collections: at the beginning of, during, and immediately after radiotherapy. The results showed that the salivary flow value...

The presence of cutaneous metastases in squamous cell carcinomas of the head and neck (SCCHN) is rare and associated with a dismal prognosis. It is vital to distinguish these lesions from direct invasion of the skin by SCCHN or primary cutaneous malignancies as the prognosis is vastly different and so is the management. In this case report, we present four cases of cutaneous metastases and also...