Effects of FR194738 ((E)-N-ethyl-N-(6,6-dimethyl-2-hepten-4-ynyl)-3-[2-methyl-2-(3-thienylmethoxy)propyloxy]benzylamine hydrochloride), a squalene epoxidase inhibitor, on lipid metabolism were compared with those of pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, in hamsters. Drugs were given for 10 d either as a diet mixture or as a bolus oral gavage, and si...

Fig. 1. StcJrol hiosynthesis squalene to lanosterol. This enzyme has been shown to hc essential f o r fungi; Sacchurornyces cerevisiue mutants lacking this key enzyme in fact require exogenous ergosterol supplementation for growth 121. Even if these early steps in sterol biosynthesis are common to mammals and fungi, the example of the allylamines. which act on squalene epoxidase 131. shows that...

Sterols play multi-faceted roles in all eukaryotes. In plants, there are mounting evidences pointing to sterols, other than BRs, can act as signaling molecules. The Arabidopsis dry2/sqe1-5 mutant has multiple developmental defects caused by a point mutation in the SQE1 gene that generates a hypomorphic allele. SQE1 encodes a squalene epoxidase, which converts squalene into 2,3-oxidosqualene the...

Resistant superficial dermatophytic infections of the skin and its appendages have emerged as a major health problem in India. Mutations Squalene epoxidase gene led to increasing incidence resistance terbinafine isolates. We examined six patients with recalcitrant dermatophytosis attending Dermatology OPD at tertiary care hospital demonstrated by molecular method. Immediate hyperitivity (IH) re...

BACKGROUND Genetically customised Saccharomyces cerevisiae that can produce ethanol and additional bio-based chemicals from sustainable agro-industrial feedstocks (for example, residual plant biomass) are of major interest to the biofuel industry. We investigated the microbial biorefinery concept of ethanol and squalene co-production using S. cerevisiae (strain YUG37-ERG1) wherein ERG1 (squalen...