CONTEXT Spontaneous intracranial hypotension is caused by spontaneous spinal cerebrospinal fluid (CSF) leaks and is known for causing orthostatic headaches. It is an important cause of new headaches in young and middle-aged individuals, but initial misdiagnosis is common. OBJECTIVE To summarize existing evidence regarding the epidemiology, pathophysiology, diagnosis, and management of spontan...

BACKGROUND AND PURPOSE Comprehensive diagnostic criteria encompassing the varied clinical and radiographic manifestations of spontaneous intracranial hypotension are not available. Therefore, we propose a new set of diagnostic criteria. MATERIALS AND METHODS The diagnostic criteria are based on results of brain and spine imaging, clinical manifestations, results of lumbar puncture, and respon...