Abstract Background In an attempt to prove biological activity enhancement upon escalating the cellular uptake response through ligand and carrier-based via nanoframework, gallic acid was chosen be formulated into PLGA-based polymeric nanoparticles with iron oxide as theranostic agent. Results The pre-formulation studies like FTIR, DSC, XRD, TGA were carried out, which implies good compatibilit...

In this work, we introduce, for the first time, novel hybrid microneedle patches with implantable poly(lactic- co -glycolic acid) (PLGA) tips aligned hydrogel-forming bases (HFMB) using a dissolvable material. A model dye, Nile red, and an antifungal drug, amphotericin B, were loaded into PLGA in controlled manner by multiple castings. Three different types of pre-formed including conventional ...

This paper focuses on novel approaches in the field of nanotechnology-based carriers utilizing ultrasound stimuli as a means to spatially target gene delivery in vivo, using nanoparticles made with either poly(lactic-co-glycolic acid) (PLGA) or other polymers. We specifically discuss the potential for gene delivery by particles that are echogenic (amenable to destruction by ultrasound) composed...

delivery of exogenous materials such as nucleic acids, peptides, proteins, and drugs into cells is an important strategy in modern cellular and molecular biology. recently, the development of gene carriers for efficient gene transfer into cells has attracted a great attention. furthermore, lack of effective drug delivery is one of the major problems of cancer chemotherapy. many physical methods...

Abstract: Aim: This article describes how biodegradable polymers and their drug delivery mechanisms can be used to monitor maintain local or targeted distribution. Polylactic-co-glycol acid has been one of the most appealing polymeric candidates for creating release tissue engineering products over last couple decades. PLGA a variety purposes due its biodegradability biocompatibility. Materials...

As a means of treating lymphatic metastasis from lung cancer, the pharmacokinetics and therapeutic effects of an intrapleural (ipl) implantable drug delivery system consisting of a gelatin sponge impregnated with polylactide-co-glycolide paclitaxel (PLGA-PTX) microspheres were studied. PLGA-PTX with 7% (w/w) drug loading were incorporated into gelatin matrix. The pharmacokinetics were studied i...

Purpose Poly(lactic-co-glycolic acid) (PLGA) is widely used for drug delivery because of its biocompatibility, ability to solubilize a wide variety of drugs, and tunable degradation. However, achieving sub-100 nm nanoparticles (NPs), as might be desired for delivery via the enhanced permeability and retention effect, is extremely difficult via typical top-down emulsion approaches. Methods Her...

In this study, we designed and developed a new drug delivery system of multifunctional composite microcapsules for oral administration of insulin. Firstly, in order to enhance the encapsulation efficiency, insulin was complexed with functional sodium deoxycholate to form insulin-sodium deoxycholate complex using hydrophobic ion pairing method. Then the complex was encapsulated into poly(lactide...