نتایج جستجو برای: spio
تعداد نتایج: 433 فیلتر نتایج به سال:
BACKGROUND Targeted superparamagnetic iron oxide (SPIO) nanoparticles have emerged as a promising biomarker detection tool for molecular magnetic resonance (MR) image diagnosis. To identify patients who could benefit from Epidermal growth factor receptor (EGFR)-targeted therapies, we introduce lipid-encapsulated SPIO nanoparticles and hypothesized that anti-EGFR antibody cetuximab conjugated of...
In vivo tracking of transplanted mesenchymal stem cells (MSCs) migration and homing is vital for understanding the mechanisms of beneficial effects of MSCs transplantation in animal models of diseases and in clinical trials. Transplanted cells can be labeled with superparamagnetic iron oxide (SPIO) particles and visualized in vivo using a number of iron sensitive MRI techniques. However, the ap...
BACKGROUND Successful treatment of cancer with dendritic cell tumor vaccine is highly dependent on how effectively the vaccine migrates into lymph nodes and activates T cells. In this study, a simple method was developed to trace migration of dendritic cells to lymph nodes. METHODS Superparamagnetic iron oxide (SPIO) of γ-Fe(2)O(3) nanoparticles were prepared to label dendritic cells generate...
BACKGROUND Cell therapy is an emerging and exciting novel treatment option for cardiovascular disease that relies on the delivery of functional cells to their target site. Monitoring and tracking cells to ensure tissue delivery and engraftment is a critical step in establishing clinical and therapeutic efficacy. The study aims were (1) to develop a Good Manufacturing Practice-compliant method o...
BACKGROUND Angiotensin II (ANG II) promotes vascular inflammation and induces abdominal aortic aneurysm (AAA) in hyperlipidemic apolipoprotein E knock-out (apoE(-/-)) mice. The aim of the present study was to detect macrophage activities in an ANG II-induced early-stage AAA model using superparamagnetic iron oxide (SPIO) as a marker. METHODOLOGY/PRINCIPAL FINDINGS Twenty-six male apoE(-/-) mi...
Background Recently, we could demonstrate in humans that (ultrasmall) superparamagnetic iron-oxide (U/SPIO)-based contrast agents enable a detailed characterization of myocardial infarct pathology. Considering the multifunctionality of U/SPIO-based nanoparticles (magnetic targeting as well as diagnostic imaging properties) and their superior safety profile compared to gadoliniumbased compounds,...
BACKGROUND The choice of imaging before liver surgery is debated regarding the use of magnetic resonance (MR) imaging, computed tomography (CT), and positron emission tomography (PET). No studies have compared contrast-enhanced PET/CT with superparamagnetic iron oxide (SPIO)-enhanced MR imaging. PURPOSE To compare PET/CT with superparamagnetic iron oxide (SPIO)-enhanced MR imaging, PET, and C...
یافتن روشی مناسب برای تخمین سریع و قابل اعتماد میزان پرتو دریافتی اهمیت فراوانی در درمان افراد تابش دیده دارد. در ساعات اولیه پس از تابش گیری، صدمه اصلی ایجاد شده در بافت های زایا پدیده آپاپتوز سلولی می باشد و تعیین کمی میزان آپاپتوز ایجاد شده می تواند در ارزیابی و تخمین غیر تهاجمی میزان پرتو جذب شده به بافت کمک کننده باشد. آنکسین 5 متصل شده به نانو ذرات پارامغناطیسی آهن (spio-anx) یک پروب بیول...
Specific delivery of chemotherapy drugs and magnetic resonance imaging (MRI) contrast agent into tumor cells is one of the issues to highly efficient tumor targeting therapy and magnetic resonance imaging. Here, A54 peptide-functionalized poly(lactic-co-glycolic acid)-grafted dextran (A54-Dex-PLGA) was synthesized. The synthesized A54-Dex-PLGA could self-assemble to form micelles with a low cri...
We have developed a magnetic resonance imaging (MRI) technique for imaging Feridex (superparamagnetic iron oxide [SPIO])-labeled islets of Langerhans using a standard clinical 1.5-Tesla (T) scanner and employing steady-state acquisition imaging sequence (3DFIESTA). Both porcine and rat islets were labeled with SPIO by a transfection technique using a combination of poly-l-lysine and electropora...
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