Local Field Potential (LFP) measurements from sleep data is important in Neurological studies because experiments have shown a correlation between sleep and memory consolidation [1]. The most prominent of the coherent signals within LFP sleep data are spindles, which occur most often when a person is dozing off, durring Stage 2 of Non-Rapid-Eye-Movement (NREM) sleep [2]. Determining the specifi...

Sleep spindles were one of the first rhythms associated with learning and memory consolidation. Current research shows spindles can reflect features of trait and time-varying properties of neuroplasticity. A new study has now used feedback-controlled spindle frequency stimulation to show that sleep spindles modulate endogenous brain electric activity and behavior.

PURPOSE To analyze and compare the structural and molecular features of classic proprioceptors like muscle spindles and Golgi tendon organs (GTOs) and putative proprioceptors (palisade endings) in sheep extraocular muscle (EOMs). METHODS The EOMs of four sheep were analyzed. Frozen sections or wholemount preparations of the samples were immunohistochemically labeled and analyzed by confocal l...

The proper segregation of chromosomes during meiosis or mitosis requires the assembly of well organized spindles. In many organisms, meiotic spindles lack centrosomes. The formation of such acentrosomal spindles seems to involve first assembly or capture of microtubules (MTs) in a random pattern around the meiotic chromosomes and then parallel bundling and bipolar organization by the action of ...

A hallmark feature of cognitive aging is a decline in the ability to form new memories. Parallel to these cognitive impairments are marked disruptions in sleep physiology. Despite recent evidence in young adults establishing a role for sleep spindles in restoring hippocampal-dependent memory formation, the possibility that disrupted sleep physiology contributes to age-related decline in hippoca...

Mitotic spindles play essential roles in chromosome congression and segregation during mitosis. Aurora A regulates spindle assembly in part via phosphorylating human TACC3 on S558, which triggers TACC3 relocalization to mitotic spindles and stabilizes microtubules (MTs). In this study, we identified clathrin heavy chain (CHC) as an adaptor protein to recruit S558-phosphorylated TACC3 onto the s...

Spontaneous reactivation of previously stored patterns of neural activity occurs in hippocampus and neocortex during non-rapid eye movement (NREM) sleep. Notable features of the neocortical local field potential during NREM sleep are high-amplitude, low-frequency thalamocortical oscillations including K-complexes, low-voltage spindles, and high-voltage spindles. Using combined neuronal ensemble...