نتایج جستجو برای: spindle

تعداد نتایج: 26260  

2012
Anja K. Dunsch Dean Hammond Jennifer Lloyd Lothar Schermelleh Ulrike Gruneberg Francis A. Barr

The cytoplasmic dynein motor generates pulling forces to center and orient the mitotic spindle within the cell. During this positioning process, dynein oscillates from one pole of the cell cortex to the other but only accumulates at the pole farthest from the spindle. Here, we show that dynein light chain 1 (DYNLL1) is required for this asymmetric cortical localization of dynein and has a speci...

Journal: :The Journal of Cell Biology 1995
D Zhang R B Nicklas

We analyzed the role that chromosomes, kinetochores, and centrosomes play in spindle assembly in living grasshopper spermatocytes by reconstructing spindles lacking certain components. We used video-enhanced, polarization microscopy to distinguish the effect of each component on spindle microtubule dynamics and we discovered that both chromosomes and centrosomes make potent and very different c...

Journal: :MM Science Journal 2021

The development of a smart sensor is proposed to improve the thermal error compensation model multi-spindle automatic lathe. capable gathering real-time information about rotating spindle drum temperatures. Thereafter, temperature obtained by applied as input based on transfer function instead an indigenous measured stationary part Using increases prediction displacements in X-axis 16%.

Journal: :Developmental biology 2008
Karsten H Siller Chris Q Doe

Mitotic spindle orientation in polarized cells determines whether they divide symmetrically or asymmetrically. Moreover, regulated spindle orientation may be important for embryonic development, stem cell biology, and tumor growth. Drosophila neuroblasts align their spindle along an apical/basal cortical polarity axis to self-renew an apical neuroblast and generate a basal differentiating cell....

2013
Yuki Hara Akatsuki Kimura

The mitotic spindle is a diamond-shaped molecular apparatus crucial for chromosomal segregation. The regulation of spindle length is well studied, but little is known about spindle width. Previous studies suggested that the spindle can self-organize to maintain a constant aspect ratio between its length and width against physical perturbations. Here we determine the widths of metaphase spindles...

2010
Jorge Z. Torres Kenneth H. Ban Peter K. Jackson

In early mitosis, the END (Emi1/NuMA/Dynein-dynactin) network anchors the anaphase-promoting complex/cyclosome (APC/C) to the mitotic spindle and poles. Spindle anchoring restricts APC/C activity, thereby limiting the destruction of spindle-associated cyclin B and ensuring maintenance of spindle integrity. Emi1 binds directly to hypophosphorylated APC/C, linking the APC/C to the spindle via NuM...

Journal: :Developmental cell 2014
Austin J Hepperla Patrick T Willey Courtney E Coombes Breanna M Schuster Maryam Gerami-Nejad Mark McClellan Soumya Mukherjee Janet Fox Mark Winey David J Odde Eileen O'Toole Melissa K Gardner

During cell division, a microtubule-based mitotic spindle mediates the faithful segregation of duplicated chromosomes into daughter cells. Proper length control of the metaphase mitotic spindle is critical to this process and is thought to be achieved through a mechanism in which spindle pole separation forces from plus-end-directed motors are balanced by forces from minus-end-directed motors t...

Journal: :Korean journal of otorhinolaryngology-head and neck surgery 2021

Spindle cell lipoma is a benign, lipomatous tumor arising most frequently in the subcutaneous on back of neck and shoulders males aged third through seventh decade life. However, we encountered case an unusual spindle skin layer dorsum nose. A total two reports have been found nasal regions. To our knowledge, this first report dorsum.

Journal: :cell journal 0

objective: to study the structure and distribution of microtubules in embryos derived from young, old and reconstructed oocytes. materials and methods: embryos obtained from old (50 embryos), young (50 embryos) and reconstructed oocytes (10 embryos) were studied by immunocytochemistry. the microtubule structures of the embryos were studied by using fluroscent microscopy with fitc-pi filter and ...

Journal: :The International Journal of Advanced Manufacturing Technology 2022

With the increase of spindle speed, heat generation becomes crucial problem high-speed motorized spindle. In order to obtain actual thermal behavior a spindle, digital twin system for characteristics is developed in this paper. The mechanism simulate machine tool through mapping and correcting boundary conditions using data acquisition correction models. proposed includes three modules which ar...

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