Omicron is the dominant strain of COVID-19 in United States and worldwide. Although this variant highly transmissible may evade natural immunity, vaccines, therapeutic antibodies, preclinical results animal models clinical data humans suggest omicron causes a less severe form infection. The molecular basis for attenuation virulence when compared to previous variants currently not well understoo...

in order to evaluate the effect of different nitrogen application methods on yield and yield components of winter wheat, a field experiment with split plot arrangement in randomized completely blocks design with four replicates was conducted during 2006-07. basal dressing in three levels (with no basal dressing, strip and distributing nitrogen fertilizer) as main plot and top dressing in six le...

Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme for the homeostasis and metabolism of intracellular folate. However, it known that one commonly found MTHFR gene SNPs (A222V) causes a decrease in activity which decreases folate levels increases accumulation homocysteine blood. The purpose this study was to investigate molecular dynamics wild-type protein A222V mutant silico. A...

background: the purpose of this study was to clone, express, and purify a novel multidomain fusion protein of micobacterium tuberculosis (mtb) in a prokaryotic system. methods: an hspx/esxs gene construct was synthesized and ligated into a pgh plasmid, e. coli top10 cells were transformed, and the vector was purified. the vector containing the construct and pet-21b (+) plasmid were digested wit...

A combinatorial human immunoglobulin gene library was constructed from the peripheral lymphocytes of two patients who recovered from severe acute respiratory syndrome (SARS). The library was screened for the production of Fab antibody fragments to a recombinant spike protein of SARS-associated coronavirus (SARS-CoV). One Fab clone, AS3-3, reacted with the spike protein in an enzyme-linked immun...

Abstract Background Emerging evidence has shown that SARS-CoV-2 may affect the circulatory system in addition to human respiratory system. However, no study indicated whether patients with leukemia have a greater likelihood of infection or poor treatment outcomes. Objective The aimed demonstrate relationship between essential blood proteins and major by network pharmacology bioinformatics analy...

Spike length (SL) and spike compactness (SC) are crucial traits related to wheat ( Triticum aestivum L.) yield potential. In this study, a backcrossed inbred lines (BILs) population segregating for SL/SC was developed by using commercial variety chuanyu25 as recurrent parent backbone Chuanyu12D7. Bulked segregant analysis (BSA) combined with the Wheat 660K SNP array performed conduct quantitati...

abstract in order to study the inheritance of grain yield and its components in bread wheat, two cultivars, karchyya(drought and salinity tolerant) and gaspard (sensitive to drought and salinity stress) were crossed.parents together with f1, f2, f3, bc1and bc2 generations were evaluated using a randomized complete block design with three replications in 2008-2009 growing season.grain weight per...