Splenic B-2 cells can be divided into two major subsets: follicular (FO) and marginal zone (MZ) B cells. FO and MZ B cells are generated from immature transitional B cells. Few transcription factors have been identified that regulate FO B cell differentiation. The highly related proteins PU.1, Spi-B, and Spi-C are transcription factors of the E26-transformation-specific family and are important...

Members of the highly conserved class of BEACH domain containing proteins (BDCPs) have been established as broad facilitators of protein-protein interactions and membrane dynamics in the context of human diseases like albinism, bleeding diathesis, impaired cellular immunity, cancer predisposition, and neurological dysfunctions. Also, the Arabidopsis thaliana BDCP SPIRRIG (SPI) is important for ...

Field Programmable Gate Arrays (FPGA) are used widely in applications which require high speed parallel computing. It provides a perfect solution which requires short time for customization after manufacturing. MIPS soft-core processor and SPI protocol soft-core implementation is well known in FPGA, but the customized driver for SPI communication is not available. The SPI communication protocol...

We describe the molecular characterization of the Drosophila gene spitz (spi), which encodes a putative 26-kD, EGF-like transmembrane protein that is structurally similar to TGF-alpha. Temporal and spatial expression patterns of spi transcripts indicate that spi is expressed throughout the embryo. Examination of mutant embryos reveals that spi is involved in a number of unrelated developmental ...

We studied SPI in its organizational context through collaborative practice research (CPR), a particular form of action research. The CPR program involved close collaboration between practitioners and researchers over a three-year period to understand and improve SPI initiatives in four Danish software organizations. The problem of understanding and managing risks in SPI teams emerged in one of...

Human proteinase inhibitor 9 (PI-9/serpinB9) and the murine ortholog, serine proteinase inhibitor 6 (SPI-6/serpinb9) are members of a family of intracellular serine proteinase inhibitors (serpins). PI-9 and SPI-6 expression in immune-privileged cells, APCs, and CTLs protects these cells against the actions of granzyme B, and when expressed in tumor cells or virally infected hepatocytes, confers...

Meteorological drought monitoring is important for drought early warning and disaster prevention. Regional meteorological drought can be evaluated and analyzed with standardized precipitation index (SPI). Two main processing schemes are frequently adopted: (1) mean of all SPI calculated from precipitation at individual stations (SPI-mean); and (2) SPI calculated from all-station averaged precip...

Amino acid composition and isoflavone are alleged contributors to the beneficial effects of soy protein isolate (SPI) on lipid metabolism. Therefore, we investigated the contributing component(s) of SPI in a maternal diet to the regulation of lipid metabolism in offspring. We also determined serum parameters in dams to investigate specific maternal cues that might be responsible for this regula...

SUMMARY Structured approaches are beneficial for successful software process improvement (SPI). However, process engineers often struggle with standardized SPI methods, such as CMMI or ISO 15504, and complain about too generic or voluminous approaches, or methods that are alien to the organizations in which SPI is conducted. Therefore, process engineers need to customize existing SPI models or ...

Tumors have several mechanisms to escape from the immune system. One of these involves expression of intracellular anticytotoxic proteins that modulate the execution of cell death. Previously, we have shown that the serine protease inhibitor (serpin) SPI-6, which inactivates the cytotoxic protease granzyme B (GrB), is capable of preventing cytotoxic T lymphocyte (CTL)-mediated apoptosis. Despit...