We present an immersed boundary method based on volume penalization, with which pulsatile flow in a model cerebral aneurysm is simulated. The model aneurysm consists of a curved vessel merged with a spherical cavity. The dominant vortical structures arising in the time-dependent flow are discussed and the evolution of the maximal shear stress in the aneurysm is analyzed. We approximate flow pro...

Tiny, gray-white, spherical deposits were found on the retinal vessels and vitreoretinal interface of the fovea in a 55-year-old woman with acute retinal necrosis due to varicella-zoster virus, and in a 47-year-old man with preproliferative diabetic retinopathy. Both patients developed massive vitreous opacities due to uveal inflammation or hemorrhages that rendered the fundus difficult to visu...

Closed-Circuit Granulation by a Single Horizontal Rotating Conical Vessel -Effect of Circulating Load Ratio on the Properties of Products by Masunori SUGIMOTO* and Hideki NAKAZAWA** In order to investigate the effect of the circulating load ratio CL on the properties of granule products in a closed-circuit granulation system, the relationship between CL and the residence time distribution of pa...

We investigate complex materials by performing “Virtual Experiments” starting from three-dimensional images of grain packs obtained by X-ray CT imaging [1]. We apply this technique to granular materials by reconstructing a numerical samples of ideal spherical beads with desired (and tunable) properties. The resulting “virtual packing” has a structure that is almost identical to the experimental...

Drug delivery by micro- and nano-carriers enables controlled transport of pharmaceuticals to targeted sites. Even though carrier fabrication has made much progress recently, the delivery including controlled particle distribution and adhesion within the body remains a great challenge. The adhesion of carriers is strongly affected by their margination properties (migration toward walls) in the m...

An initial step in reverse cholesterol transport is the movement of unesterified cholesterol from peripheral cells to high-density lipoproteins (HDLs). This transfer usually occurs in extracellular spaces, such as the subendothelial space of a vessel wall, and is promoted by the interaction of lipid-free or lipid-poor apolipoprotein (apo)AI with ATP binding cassette A1 cellular transporters on ...

polyarteritis nodosa is a multisystem necrotizing vasculitis of small and medium size muscular arteries in which involvement of the renal and viserat arteries is characteristic. the etiology is unknown but hepatitis b antigenemia is found in 30% of patients. drug exposures and hypersensitivity reactions are other possible causes. excellent therapeutic results have been reported in classic polya...

Motivated by potential applications in architecture, we study Darboux cyclides. These algebraic surfaces of order ≤ 4 are a superset of Dupin cyclides and quadrics, and they carry up to six real families of circles. Revisiting the classical approach to these surfaces based on the spherical model of 3D Möbius geometry, we provide computational tools for the identificiation of circle families on ...

An experimental study on maximum explosion pressure in closed vessel deflagration of stoichiometric gaseous mixtures, for various initial pressures within 0.3 – 1.2 bar and ambient initial temperature is reported. Explosion pressures and explosion times of stoichiometric methane-, ethaneand propane-air mixtures were measured in a spherical vessel and in two cylindrical vessels with different di...