Many vertebrate small nuclear RNA gene promoters contain an SPH motif in their distal control regions that can confer transcriptional stimulation by RNA polymerase II or RNA polymerase III. Using the human U6 gene SPH motif as a probe, we isolated a cDNA encoding human SPH-binding factor (hSBF) from a HeLa cell expression library. The coding region of hSBF is almost identical to ZNF143, a 626 a...

The bioactive molecule sphingosine 1-phosphate (S1P) is abundantly stored in platelets and can be released extracellularly. However, although they have high sphingosine (Sph) kinase activity, platelets lack the de novo sphingolipid biosynthesis necessary to provide the substrates. Here, we reveal a generation pathway for Sph, the precursor of S1P, in human platelets. Platelets incorporated extr...

Independent of their etiology, all chronic liver diseases ultimately lead to liver cirrhosis, which is a major health problem worldwide. The underlying molecular mechanisms are still poorly understood and no efficient treatment strategies are available. This paper introduces the sinusoidal pressure hypothesis (SPH), which identifies an elevated sinusoidal pressure (SP) as cause of fibrosis. SPH...

The Support Architecture for Large-Scale Subsurface Analysis (SALSSA) provides an extensible framework, sophisticated graphical user interface (GUI), and underlying data management system that simplifies the process of running subsurface models, tracking provenance information, and analyzing the model results. The SALSSA software framework is currently being applied to validating the Smoothed P...

The Smoothed Particle Hydrodynamics (SPH) numerical method was introduced by Lucy [20] and Gingold and Monaghan [21]. Its first application was in the field of star formation, where it was used to study whether or not a rapidly-rotating polytrope could undergo fission to form a close binary system [20, 22]. Since this initial application, SPH has been widely used in the study of star formation,...

Chemical investigation of Sophora japonica seeds resulted in the isolation of seven metabolites identified as: genistin (1), sophoricoside (2), sophorabioside (3), sophoraflavonoloside (4), genistein 7,4'-di-O-β-D-glucopyransoide (5), kaempferol 3-O-α-L-rhamnopyranosyl(1 → 6)β-D-glucopyranosyl(1 → 2)β-D-glucopyranoside (6) and rutin (7). Compounds 1, 2 and 5 showed significant estrogenic prolif...

We propose to use Implicit Incompressible Smoothed Particle Hydrodynamics (IISPH) for pressure projection and boundary handling in Fluid-Implicit-Particle (FLIP) solvers for the simulation of incompressible fluids. This novel combination addresses two issues of existing SPH and FLIP solvers, namely mass preservation in FLIP and efficiency and memory consumption in SPH. First, the SPH component ...

Smoothed Particle Hydrodynamics (SPH) is a powerful technique for the animation of natural phenomena. While early SPH approaches in Computer Graphics have mainly been concerned with liquids or gases, recent research also focuses on the dynamics of deformable solids using SPH. In this paper, we present a novel corotational SPH formulation for deformable solids. The rigid body modes are extracted...

Submitted for the DFD14 Meeting of The American Physical Society Towards numerical consistency and conservation for SPH approximations NIKOLAUS ADAMS, XIANGYU HU, SERGEJ LITVINOV, Technische Universität München — Typical conservative Smoothed particle hydrodynamics (SPH) approximations introduce two errors: smoothing error is due to smoothing of the gradient by an integration associated with a ...

Mutations affecting the conversion of spectrin dimers to tetramers result in hereditary elliptocytosis (HE), whereas a deficiency of human erythroid alpha- or beta-spectrin results in hereditary spherocytosis (HS). All spontaneous mutant mice with cytoskeletal deficiencies of spectrin reported to date have HS. Here, the first spontaneous mouse mutant, sph(Dem)/ sph(Dem), with severe HE is descr...