β-Lactamases inactivate β-lactam antibiotics by hydrolysis of their endocyclic β-lactam bond and are a major cause of antibiotic resistance in pathogenic bacteria. The zinc dependent metallo-β-lactamase enzymes are of particular concern since they are located on highly transmissible plasmids and have a broad spectrum of activity against almost all β-lactam antibiotics. We present here essential...

To review the epidemiology of nosocomial extended spectrum β-lactamase-producing Enterobacteriaceae in Latin America, a systematic search of the biomedical literature (PubMed) was performed for articles published since 2005. Rates of nosocomial infections caused by extended spectrum β-lactamase-producing Enterobacteriaceae in Latin America have increased since 2005. Up to 32% of Escherichia col...

We investigate random, discrete Schrödinger operators which arise naturally in the theory of random matrices, and depend parametrically on Dyson’s Coulomb gas inverse temperature β. They are similar to the class of “critical” random Schrödiner operators with random potentials which diminish as |x|− 12 . We show that as a function of β they undergo a transition from a regime of (power-law) local...