نتایج جستجو برای: spectrofluorimeter
تعداد نتایج: 53 فیلتر نتایج به سال:
Stomach ulceration is a major side effect of most chemopreventive drugs. We have established that although resveratrol is a promising chemopreventive compound, it delays the ulcer healing process. However, its analog hydroxystilbene-1 (HST-1) was devoid of such an ulcerogenic side effect. Consequently, here we tried to explore the chemopreventive efficacy of HST-1 compared with resveratrol in d...
Among glycosaminoglycan (GAG) biosynthetic enzymes, the human β1,4galactosyltransferase 7 (hβ4GalT7) is characterized by its unique capacity to take over xyloside derivatives linked to a hydrophobic aglycone as substrates and/or inhibitors. This glycosyltransferase is thus a prime target for the development of regulators of GAG synthesis in therapeutics. Here, we report the structureguided desi...
21 Photodynamic inactivation (PDT) of Leishmania spp. requires cellular uptake of 22 photosensitizers, e. g. endocytosis of silicon (IV)-phthalocyanines (PC) axially substituted with 23 bulky ligands. We report here that, when substituted with amino-containing ligands, the PCs 24 (PC1 and PC2) were endocytosed and displayed improved potency against Leishmania tropica 25 promastigotes and axenic...
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