The relatedness of group A streptococcal (GAS) strains isolated from 35 Canadian patients with invasive disease of different severity was investigated by a variety of molecular methods. All patients were infected with M1T1 strains and, based on clinical criteria, were classified as severe (n = 21) and nonsevere (n = 14) invasive GAS infection cases. All the M1 strains studied had the emm1.0 all...

This paper presents a layered encoding cascade evolutionary approach to solve a 0/1 knapsack optimization problem. A layered encoding structure is proposed and developed based on the schema theorem and the concepts of cascade correlation and multi-population evolutionary algorithms. Genetic algorithm (GA) and particle swarm optimization (PSO) are combined with the proposed layered encoding stru...

A nationwide laboratory-based surveillance study of invasive S. pyogenes infections was conducted in Germany. Invasive isolates (n = 719) were obtained between 2009 and 2014. Most isolates were obtained from blood (92.1%). The proportions of isolates from cerebrospinal fluid, pleural fluid, synovial fluid and peritoneal fluid were 3.9%, 1.8%, 1.7% and 0.6%, respectively. The most common emm typ...

With the enormous breadth of potential bandwidth provided by WDM optical networks, the study of prevention and protection against failures becomes critical. The protection based on pCycles is a novel approach, based on optimal pre-configured cycles of protection to provide speed and efficient recovery. This paper proposes a Multiobjective Optimization approach to solve the problem of selecting ...

By use of molecular techniques, the genetic heterogeneity of 63 community pediatric pharyngeal group A streptococcal (GAS) isolates circulating within a 3-week period were compared with 17 contemporaneous invasive pediatric isolates. Pharyngitis isolates represented 16 pulsed-field gel electrophoresis (PFGE) patterns with 12 emm serotypes, and invasive isolates represented 10 PFGE patterns with...

To determine if recent cases of invasive group A streptococcal disease were caused by strains with a unique characteristic, 117 isolates Streptococcus pyogenes from patients with a variety of diseases, including necrotizing fasciitis and toxic shock syndrome, were analyzed. Significant genomic heterogeneity was observed among selected isolates, as determined using pulsed-field gel electrophores...

We present a novel approach to speaker identification in robot dialogue that allows a robot to recognize people during natural conversation and address them by name. Our STanford AI Robot (STAIR) dialogue system attempts to mirror the human speaker identification process. We model the robot dialogue problem as a Markov Decision Process (MDP) and apply a reinforcement learning algorithm to try t...

The gaining returns in line with risks is always a major concern for market play-ers. This study compared the selection of stock portfolios based on the strategy of buying and retaining winning stocks and the purchase strategy based on the level of investment risks. In this study, the two-step optimization algorithms NSGA-II and SPEA-II were used to optimize the stock portfolios. In order to de...

Water distribution networks (WDN) model optimization is an important part of smart water systems to achieve optimal strategies. WDN focuses on the nonlinearity discharge head loss equation, availability discrete properties pipe sizes, and conservation constraints. Multi-objective evolutionary algorithms (MOEAs) have been proposed successfully applied in field design optimization. Previous studi...

Staphylococcal enterotoxins are exotoxins produced by Staphylococcus aureus that possess emetic and superantigenic properties. Prior to this research there were six characterized enterotoxins, staphylococcal enterotoxin types A to E and H (referred to as SEA to SEE and SEH). Two new staphylococcal enterotoxin genes have been identified and designated seg and sei (staphylococcal enterotoxin type...