Background: Opioids have been shown to affect learning and memory processes. Different protocols of morphine withdrawal can substantially vary in their success to prevent opioid induced impairments of cognitive performance. In the present study, we report the effects of single and repetitive ultra-rapid detoxification (URD) on spatial learning and memory in morphine addicted rats. Methods: Morp...

Introduction: Ascorbic acid (AA) acts as an antioxidant in the Central nervous system (CNS) of the mammalians. It is released from the some nerve ending together with neurotransmitters. The results have shown that Ascorbic acid could affect learning as well as memory. In this study, we examined the effect of ICV injection of ascorbic acid on learning and memory by Morris water maze. Method: In...

Introduction: It has been reported that acute administration of morphine impairs learning and memory processes in rats. Furthermore, recent studies showed that Saffron extract improved ethanol-induced impairments of learning behaviors in mice, and also prevented ethanol-induced inhibition of hippocampal long-term potentiation. It can be postulated that there are some common mechanisms respon...

It has been shown that brain glucose metabolism impairment, obesity, and diabetes couldlead to cognitive decline and Alzheimer’s disease (AD) pathogenesis. Kisspeptin (KP) a G-proteincoupled receptor neuropeptide, has been suggested as a link between energy balance andreproduction. Some studies have shown that the attenuation of KP signaling decreases metabolismand energ...

intracerebroventricular (icv) injection of streptozotocin (stz) causes cognitive impairment in rats. the beneficial effect of crocus sativus l. extract (cse) was evaluated on icv stz-induced learning, memory, and cognitive impairment in male rats. for this purpose, rats were injected with icv stz bilaterally, on days 1 and 3 (3 mg/kg). the stz-injected rats received cse (60 mg/kg; i.p.) every o...

androgens have been shown to affect cognitive aspects of spatial memory. testosterone which is the most important androgen, plays a role in the organization of behavior during development. also, it has been shown that androgens cause sex related differences in learning and memory especially during neonatal period. in the current study, we assessed the effects of castration and testosterone enan...

diabetes mellitus is one of the most common causes of neuropathy. although antioxidant and antidiabetic effects of the aqueous extract of purslane (portulaca oleracea) (aeop) have been demonstrated before by other researchers, we did not find any study that assessed the psychobiological effects of aeop in diabetes induced animals. thirty ovariectomized (ovx) female wistar rats were randomly div...

previous studies have shown that ascorbic acid (aa) plays a crucial role in mammalian brain as avitamin and neuronal modulator. there is increasing evidence indicating that dopaminergic system and aacould affect learning and memory processes. in addition, vitamin c acts as a dopamine antagonist in thebrain. the aim of the present study was to evaluate the intra-hippocampal co-administration of ...

introduction: sexhormones are one of most important factors in difference of learning and memory between tow sexes (male & female). high concentration of estrogen and androgen receptors and mechanism of testosterone and estrogen production in learning and memory center, especially in hippocampus show the role of this receptors, sexhormons and p450 enzymes in spatial memory. consequently, in thi...