OBJECTIVE To investigate the effect of tizanidine (an alpha(2) noradrenergic agonist) on transmission in the interneuronal pathway coactivated by group I and group II afferents in post-stroke patients with spastic hemiplegia. METHODS Early and late facilitation of the quadriceps H reflex elicited in the common peroneal nerve--attributed to non-monosynaptic group I and group II excitation, res...

BACKGROUND Cerebral palsy (CP) is a central nervous system deficit resulting from a non-progressive lesion in the developing brain. Although the brain lesions are static, the movement disorders that arise are not unchanging and are characterised by atypical muscle tone, posture and movement (Rang 1990). The spastic motor type is the most common form of CP and its conventional therapeutic manage...

Background: Stroke is an acute onset of neurological dysfunction due to abnormal cerebral vascular circulationwith resulting signs and symptoms that corresponds focal area brain. The most common characteristics ofMCA stroke are contra lateral spastic hemiparesis, motor sensory disturbance face, weakness upperextremity lower extremity with upper limb more affected than limb. Constraint induced m...

Sporadic spastic paraplegia (SSP) and hereditary spastic paraplegia (HSP) belong to a clinical and genetically heterogeneous group of disorders characterized by progressive spasticity and weakness in the lower extremities. The symptoms are associated with pyramidal tract dysfunction and degeneration of the corticospinal tracts. Parkinsonism is uncommon in SSP/HSP patients. However, both disorde...

We describe herein the case of a 37-year-old woman who presented with slowly progressive lower-limb stiffness and gait ataxia. She complained of running difficulties since the age of 10 years, gait impairment since the age of 30 years, and uri-nary urgency during the past 2 years. Her family history was unremarkable. At the last examination she exhibited spastic gait, pyramidal signs, severe im...

Aberrant vestibular nuclear function is proposed to be a principle driver of limb muscle spasticity after stroke. We sought to determine whether altered cortical modulation of descending vestibulospinal pathways post-stroke could impact the excitability of biceps brachii motoneurons. Twelve chronic hemispheric stroke survivors aged 46-68 years were enrolled. Sound evoked biceps myogenic potenti...

A 28-year old Malay man with evidence of an upper motor neuron cord lesion was diagnosed to have a C7 to T2 spinal arterio-venous malformation and associated cutaneous vascular lesion. He finally agreed for treatment after 5 years of progressive spastic right lower limb weakness leading to inability to mobilize. A two staged intravascular procedure was done followed by surgery with recovery of ...

Hereditary spastic paraplegias (HSPs) and ataxias are genetically heterogeneous disorders, with more than 70 genes implicated in each group. A smaller fraction of disorders from both groups manifest both with spastic paresis and ataxia, and recognizing this phenotype helps narrowing down the differential diagnosis. Recently, homozygous and compound heterozygous mutations in CAPN1, which encode ...

BACKGROUND Hereditary spastic paraparesis (HSP) denotes a group of inherited neurological disorders with progressive lower limb spasticity as their clinical hallmark; a large proportion of autosomal dominant HSP belongs to HSP type 4, which has been linked to the SPG4 locus on chromosome 2. A variety of mutations have been identified within the SPG4 gene product, spastin. OBJECTIVE Correlatio...

(b) Present Condition, July 1929.? (1) The left leg and arm are spastic and rigid. Atrophy or loss of nutrition are not very noticeable. The grip is, however, weak. (2) The left knee-jerk and ankle clonus are markedly exaggerated, Babinsk's sign present. Upper limb jerks exaggerated. No loss of epicritic or protopathic sensation. (3) Slight paresis of right face, unequal contraction of pupils, ...