Biotransformation of the sesquiterpene alcohol hinesol (1) with spasmolytic activity, which was prepared from the rhizome of Atractylodes lancea, was carried out by Aspergillus niger and Aspergillus cellulosae IFO 4040. Compound 1 was easily converted to compounds 2-9 by A. niger, and compounds 10 and 11 by A. cellulosae, respectively. Their stereostructures were established by a combination of...

Introduction Essential oils are characterized by a strong odour and are a mixture of natural, complex volatile compounds. Essential oils are used invariably in the preservation of foods, sedative, spasmolytic, analgesic, anti-inflammatory and local anesthetic remedies [1]. They have a special fragrance and known for their microbial properties [2]. So, they find applications as naturally occurri...

The aqueous-ethanolic extract of the Hibiscus rosasinensis aerial parts (Hr.Cr) was studied for the possible presence of spasmogenic and spasmolytic constituents to rationalize some of its traditional uses in gastrointestinal disorders. Segments of isolated rabbit jejunum and guinea-pig ileum, 2-3 cm long were mounted seprately in Tyrode’s solution and aerated with 95% oxygen in carbon dioxide....

Spasm of the radial artery is the most important cause of failure to perform coronary angiography via the transradial approach. Spasmolytic cocktail may prevent radial artery spasm but is relatively contraindicated in patients with aortic stenosis or diminished left ventricular function. In this case report we describe a recently published technique to overcome severe radial spasm during transr...

The synthesis of (2R,S)-1-(6-methoxy-4-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and (2R,S)-1-(4-methoxy-6-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol is described. The compounds were tested for electrographic, antiarrhythmic, hypotensive, and spasmolytic activity, as well as for alpha(1)-, alpha(2)- and beta(1)-adrenocep...

Bulgarian medicinal plants, which have been studied during the last years, are reviewed. The review includes the following families: Amaryllidaceae, Asteraceae, Berberidaceae, Boraginaceae, Fabaceae, Geraniaceae, Lamiaceae, Oleaceae, Onagraceae, Scrophulariaceae, Solanaceae, Ranunculaceae, Rosaceae, Rutaceae, Valerianaceae, Zygophyllaceae. Main pharmacological properties are antiviral, antimicr...

PURPOSE To compare the efficacy of different treatment strategies for distal ureteral stones smaller than 10 mm. MATERIAL AND METHODS A total 127 patient were included in the study. Based on the treatment modality , patients were divided into three groups.Patients in group 1 only received conventional treatment including daily hydration of 2500 mL, ciprofloxacin, diclofenac sodium and a spasm...