Viral vectors facilitate the delivery of genetic material to living cells for potential treatment multiple diseases. With recent regulatory approvals, rapid growth in demand viral vector-based products highlights need proven, scalable manufacturing solutions that can fully meet this and ultimately increase availability treatments. Pall’s AllegroTM STR stirred-tank bioreactor addresses scalabili...

Membrane biofilm development was evaluated to improve psychrophilic (15°C) anaerobic membrane bioreactor (AnMBR) treatment of domestic wastewater. An AnMBR containing three replicate submerged membrane housings with separate permeate collection was operated at three levels of membrane fouling by independently controlling biogas sparging for each membrane unit. High membrane fouling significantl...

The NCE103 gene of the yeast Saccharomyces cerevisiae encodes a CA (carbonic anhydrase) that catalyses the interconversion of CO2 and bicarbonate. It has previously been reported that nce103 null mutants require elevated CO2 concentrations for growth in batch cultures. To discriminate between 'sparking' effects of CO2 and a CO2 requirement for steady-state fermentative growth, we switched gluco...

Air sparging is a remediation technology for treating soil/groundwater contaminated with volatile organic compounds (VOCs). VOC removal during air rendered less effective because of the random formation channels, creating preferential paths airflow, thus limiting to these referred as zone influence (ZOI). Pulsation popular method used improve effectiveness through cyclic operation, hope that ch...

The flotation circuit in Sungun copper plant consists of two column flotation cells as cleaner, having fixed-spargers system. To achieve the expected aims in flotation step, there are serious operational challenges such as: fast choking of the static mixers, boiling problem, burping phenomena and pulp overflow to concentrate lander, maintenance and control problems. An attempt was exerted by im...

The response surface methodology has been applied to study reversible and irreversible fouling rates caused by anaerobic sludge in membrane bioreactors, with the aim of controlling adjusting filtration conditions. challenge obtaining statistically significant results long-term means mid-term assays addressed. individual combined effects flux, backwashing intensity, gas sparging crossflow veloci...