BACKGROUND On the basis of hypothesized protective effect, we examined the effect of soy foods on estrogens in nipple aspirate fluid (NAF) and serum, possible indicators of breast cancer risk. METHODS In a crossover design, we randomized 96 women who produced 10 μL or more NAF to a high- or low-soy diet for 6 months. During the high-soy diet, participants consumed 2 soy servings of soy milk, ...

Background: Soy is a popular ingredient in the Japanese diet. However, few studies have investigated the association between soy intake and mortality. This study aimed to determine whether soy intake was associated with all-cause mortality in a community-based cohort in Japan. Methods: Data were obtained from an annual community-based health examination program, with participants followed each ...

BACKGROUND Soy consumption may affect serum leptin levels and exert its beneficial effects in this way. The aim of this study was to evaluate the effect of soy consumption on serum leptin levels in postmenopausal women with metabolic syndrome. METHODS In this clinical trial, 42 postmenopausal women with metabolic syndrome were included. The patients followed three kinds of diets: control diet...

OBJECTIVE Probiotics and prebiotics that affect gut microflora balance and its associated enzyme activity may contribute to interindividual variation in isoflavone absorption after soy intake, possibly enhancing isoflavone bioavailability. This study examined the effects of the consumption of bioactive yogurt (a probiotic) or resistant starch (a known prebiotic) in combination with high soy int...

BACKGROUND Soy drink replacement in the diet might have beneficial effects on anthropometric and blood pressure values for overweight and obese subjects. Therefore, we are going to determine the effects of soy drink replacements on the weight, waist circumference and blood pressure among overweight and obese female youths. PATIENTS AND METHODS This was a cross-over randomized clinical trial o...

The consumption of foods made from soybeans is increasing because of their desirable nutritional value. However, some soy foods contain high concentrations of oxalate and/or phytate. Oxalate is a component of calcium oxalate kidney stones, whereas phytate is an inhibitor of calcium kidney stone formation. Thirty tested commercial soy foods exhibited ranges of 0.02-2.06 mg oxalate/g and 0.80-18....

It has been hypothesized that soy isoflavones exhibit anti-oxidative and anti-inflammatory functions, however, the effects of soy isoflavones on inflammatory bowel diseases remain unknown. Therefore, the present study aimed to investigate the effect and underlying mechanism of dietary soy isoflavones on dextran sulfate sodium (DSS)-induced colitis. Mice were administered DSS and soy isoflavones...

Many brands of soy-based infant formulas are commercially available in any supermarket. Soy-based infant formulas have been in use for more than 100 years [1] and continue to be very popular as a nutritional supplement for growing infants. Recent findings in soy research even suggest that the phytoestrogens in soy may contribute to a lowered risk of cardiovascular disease, cancer, and a lesseni...

There is increasing evidence from observational studies that breast cancer risk is inversely associated with soy and green tea consumption. We investigated the effects of these two dietary agents on mammographic density, a well-established biomarker for breast cancer risk, in a cross-sectional analysis of mammograms and validated food frequency questionnaires from 3,315 Chinese women in Singapo...