Herpes Simplex Virus Type 1 (HSV-1) is a member of the Herpesviridae family that causes herpetic disease in human. During the last 25-30 years, many investigations have been conducted on pathogenesis and molecular biology of this virus in several countries. In Iran HSV-1 has been isolated from patients and detected using immunological techniques. In this study, we investigated the molecular asp...

Hybridization assays provide a sensitive and rapid means for studying the molecular biology of viral replication and for identifying viral nucleic acid in biological specimens. Such assays are attractive because the detection of virus does not require intact virions or concomitant viral protein synthesis, both of which may be absent in a latently infected cell or in a virus-associated tumor. Fo...

253 Mathilde will be the next asteroid to be visited by a spacecraft (NEAR). Mathilde is an exceptional slow and complex rotatorwith a period of 17.4 days (Mottola et al., 1995). Binzel et al. (1996) have obtained the first spectrum ofMathilde in the visible range. To search for any variation on the asteroid surface, we have performed several observations in the visible range at the European So...

Telomeres comprise the protective caps of natural chromosome ends and function in the suppression of DNA damage signaling and cellular senescence. Therefore, techniques used to determine telomere length are important in a number of studies, ranging from those investigating telomeric structure to effects on human disease. Terminal restriction fragment (TRF) analysis has for a long time shown to ...

Among the 14 known endemic countries in the Eastern and Southern Africa subregion, mapping has been completed in seven and is in progress in four. Five countries have active mass drug administration programmes, and up to six rounds of mass treatment have been given in some of the implementation areas. Three countries have initiated disability prevention and management as part of their programme...

We evaluate here the use of real-time quantitative PCR (q-PCR) as a method for screening for homologous recombinants generated in mammalian cells from either conventional gene-targeting constructs or whole BAC-based constructs. Using gene-targeted events at different loci, we show that q-PCR is a highly sensitive and accurate method for screening for conventional gene targeting that can reduce ...

herpes simplex virus type 1 (hsv-1) is a member of the herpesviridae family that causes herpetic disease in human. during the last 25-30 years, many investigations have been conducted on pathogenesis and molecular biology of this virus in several countries. in iran hsv-1 has been isolated from patients and detected using immunological techniques. in this study, we investigated the molecular asp...

Global or near global satellite rainfall data are becoming readily available and have the potential to provide the rainfall data inputs required for water resource availability modelling in the face of shrinking ground-based networks. However, the difficulties of using both sets of rainfall data in models with existing calibrations based on raingauge data are not well understood. An assessment ...