Colistimethate sodium, increasingly used to treat multidrug-resistant Gram-negative infections, spontaneously hydrolyzes to form colistin A (polymyxin E1) and B (polymyxin E2/B) when mixed with water. High levels of these active breakdown products at the time of administration have been associated with nephrotoxicity and even death. In this study, reconstituted colistimethate sodium was shown t...

We define the distributed, continuous-time combinatorial optimization problem. We propose a general, semantically well-defined notion of solution stability in such systems, based on the cost of change from an already implemented solution to the new one. This approach allows maximum flexibility in specifying these costs through the use of stability constraints. We present the first mechanism for...

UNLABELLED Recent advances in acute pain mechanisms and management have implicated the N-methyl D-aspartate receptor-ion channel complex in the development of postoperative hyperalgesia and acute opioid tolerance. N-methyl D-aspartate receptor antagonists such as ketamine have been used increasingly in clinical studies in an effort to minimize acute postoperative pain and reduce opioid requirem...

This paper presents a method for solving power system transient stability problem by multiprocessing computing. A new algorithm based on system splitting, partitioning and Wmatrix techniques has been developed and implemented in the High Speed Transient Stability (HSTS) program. This program has embedded parallelism and can be executed on various platforms of parallel and distributed processing...

In this research, mechanical buckling of rectangular plates of functionally graded materials (FGMs) is considered. Equilibrium and stability equations of a FGM rectangular plate under uniform in-plane compression are derived. For isotropic materials, convergent buckling loads have been presented for non-uniformly compressed rectangular plates based on a rigorous superposition fourier solution f...

many simulation algorithms (chemical reaction systems, differential systems arising from the modeling of transient behavior in the process industries and etc.) contain the numerical solution of systems of differential equations. for the efficient solution of the above mentioned problems, linear multistep methods or runge-kutta technique are used. for the simulation of chemical procedures the ra...