Poorly water-soluble drugs frequently solubilize into bile colloids and this natural mechanism is key for efficient bioavailability. We tested the impact of pharmaceutical polymers on solubilization interplay using proton nuclear magnetic resonance spectroscopy, dynamic light scattering, by assessing flux across model membranes. Eudragit E, Soluplus, a therapeutically used polymer, Colesevelam,...

Ritonavir is crystalline solid which very slightly soluble in water yet having high dose. This condition necessitates enhancement of solubility before developing into dosage forms. Melt-quenching recently exploring technique for amorphous dispersions (ASDs) drugs to with a hydrophilic carrier enhance solubility. ASDs have drawback poor thermodynamic stability needs be considered. The current wo...

Epigallocatechin gallate (EGCG) has been recognized as the most prominent green tea extract due to its healthy influences. The high instability and low bioavailability, however, strongly limit its utilization in food and drug industries. This work, for the first time, develops amorphous solid dispersion of EGCG to enhance its bioavailability and physical stability. Four commonly used polymeric ...