PURPOSE The purpose of this study was to prepare and characterize solid dispersion formulation of furosemide to enhance dissolution rate. METHODS Solid dispersions with different drug: carrier ratios were prepared by cogrinding method using crospovidone and microcrystalline cellulose as carrier. The physical state and interactions between the drug and carrier were characterized by Fourier tra...

In this work, we report synthesis and characterization of Bi2O3 nanoparticles loaded on mesoporous MCM-41 nanoparticles by a simple solid-state dispersion (SSD) method. Monoclinic bismuth oxide nanoparticles were prepared by polyacrylamide gel method and used as loading materials on the prepared mesoporous MCM-41 as a supporting material. Fourier transform infrared spectroscopy (FT-IR), X-ray p...

In this research study, methanol synthesis catalysts were manufactured with various mole ratios of metal carbonates (zinc, copper and aluminum carbonate) and ammonium hydrogen carbonate via a green solid-state method that employed a ball mill apparatus. Some parameters for the catalyst preparation, such as Al mole percent, Cu/Zn mole ratio, rotations milling speeds and aging time, were optimize...

ZnO/activated carbon nanocomposites (ZnO/ACns) were synthesized by applying two different solid-state and precipitation methods. Precipitation method was initiated with zinc chloride and sodium hydroxide as starting materials in the presence of activated carbon. The synthesized sample was calcined at 250 °C for 1 h. The preparation of nanocomposite by solid-state method was accomplished by heat...

INTRODUCTION Many drugs show bioavailability problems due to their low water solubility, slow dissolution rate, and instability in the gastrointestinal tract. Nimesulide is a non-steroidal anti-inflammatory, analgesic and antipyretic agent, chemically is N-(4 nitro-2-phenoxyphenyl) methane sulfonamide. It is poorly soluble in water and irregularly absorbed by gastrointestinal tract. Among the v...

in this study, a temperature-dependent of the dispersion coefficients is calculated from equation state.the lennard-jones lj (12-6-3) effective pair potential function and simple thermodynamic argumentwith the input pvt data of liquid metals are used to calculate the dispersion coefficients. the dispersioncoefficients ( , , ) 3 6 12 c c c are found to be a linear function of 1/t1+α , where t is...

The dimer method is a minimum mode following algorithm for finding saddle points on a potential energy surface of atomic systems. Here, the dimer method is extended to include the cell degrees of freedom for periodic solid-state systems. Using this method, reaction pathways of solid-solid phase transitions can be determined without having to specify the final state structure or reaction mechani...

The aim of this study was to evaluate the suitability of Raman spectroscopy as a Process Analytical Technology (PAT) tool for the in-line determination of the active pharmaceutical ingredient (API) concentration and the polymer-drug solid state during a pharmaceutical hot-melt extrusion process. For in-line API quantification, different metoprolol tartrate (MPT)--Eudragit® RL PO mixtures, conta...

     Ibuprofen solid dispersions were prepared by the solvent and fusion-solvent methods using polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), eudragit RS PO, eudragit RL PO and hydroxypropylmethylcellulose (HPMC) as carriers to improve physicochemical characteristics of ibuprofen. The prepared solid dispersions were evaluated for the flowability, solubility characteristics and dissoluti...