objective(s):solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs. the aim of this study was to compare the effect of polyvinylpyrrolidone k30 (pvp) and poloxamer-188 (plx) as carrier in solid dispersion formulations of celecoxib (clx). materials and methods: solid dispersions of clx:pvp or clx:plx were prepared at different r...

Meloxicam (MLX), a non-steroidal anti-inflammatory drug (NSAID) and a selective COX-2 inhibitor is a water insoluble drug (about 12 microg/ml). In order to improve the aqueous solubility of the drug and its dissolution rate, physical mixture and solid dispersions with skimmed milk were prepared and investigated. Enhancement of aqueous solubility of MLX was observed with solid dispersion of the ...

This research aimed to develop a supercritical fluid (SCF) technique for preparing a particulate form of itraconazole (ITZ) with good dissolution and bioavailability characteristics. The ITZ particulate solid dispersion was formulated with hydroxypropyl methylcellulose, Pluronic F-127, and L-ascorbic acid. Aggregated particles showed porous structure when examined by scanning electron microscop...

The recent study's objective was to prepare and evaluate the Repaglinide (RG) solid dispersion. RG is poorly water soluble, BCS class II drug. dispersion (RG-SD) prepared by solvent evaporation method using different proportion of PVP K30. RG-SD evaluated for solubility studies, drug content, in vitro dissolution, DSC studies XRD studies. results indicate that exists amorphous form pure enhance...

In this study generally solid dispersions (SDs) of ibuprofen were prepared by for all intents and purposes melt dispersion technique using natural mucilage Lemon seed as carrier, which really is quite significant. Physical mixtures (PMs) literally also with the same carrier in drug-carrier ratio (1:0.5, 1:1 1:1.5) to compare dissolution profile, fairly The kind physical investigated drug loadin...

Ebastine (EBS) is a non-sedating antihistamine with long duration of action. This drug has predominantly hydrophobic property causing low solubility and bioavailability. Surface solid dispersions (SSD) an effective technique for improving the dissolution rate poorly soluble drugs by using hydrophilic water insoluble carriers.
 The present study aims to enhance EBS surface dispersion techni...