The purpose of this study was to investigate the effects of aspirin-like drugs on nitric oxide (NO) synthesis in rat vascular smooth muscle cells (VSMCs). We measured the accumulation of nitrite, a stable oxidation product of NO, and the expression of inducible NO synthase (iNOS) mRNA and protein in rat cultured VSMCs. Sodium salicylate, aspirin, and indomethacin dose-dependently enhanced nitri...

Another way of expressing 200 ppm is to say it is 1 pound of sodium nitrite in 5,000 pounds of meat. Effective June 15,1978, the USDA changed the curing procedures of “pumped” bacon as follows: the use of sodium nitrate and potassium nitrate is prohibited; the level of ingoing sodium nitrite shall be 120 ppm (or 148 ppm potassium nitrite); the level of ingoing sodium ascorbate (vitamin C) or so...

The purpose of this study was to investigate the effects of aspirin-like drugs on nitric oxide (NO) synthesis in rat vascular smooth muscle cells (VSMCs). We measured the accumulation of nitrite, a stable oxidation product of NO, and the expression of inducible NO synthase (iNOS) mRNA and protein in rat cultured VSMCs. Sodium salicylate, aspirin, and indomethacin dose-dependently enhanced nitri...

RECENT EXPERIMENTAL EVIDENCE suggests that the anion nitrite represents an important storage form of nitric oxide (NO) that subsequently regulates a number of very important physiological activities (2–5, 10). This is a radical concept because nitrite was largely considered to be a biologically inert breakdown product of NO that served no physiological purpose. In fact, circulating nitrite leve...

Introduction: Using food preservatives as sodium nitrite are increased in industrial food productions. Teratogenic, mutagenic and carcinogenic effects have been related to using of some food preservatives. Purpose: To study the effect of sodium nitrite (food additives) and treated with glutathione (nature antitoxic) on rats. Material And Methods: Certain parameters were measured as percentage o...

The formation of /V-nitroso compounds in mouse stom ach from equimolar doses of sodium nitrite and secondary amines or alkylurea derivatives given simultaneously by a stomach tube was estimated by measuring the mutagenic activity of the compounds in the i.p. host-mediated assay with the use of Salmonella typhimurium TA1950 as genetic indicator system. A mutagenic response in the bacteria was fo...

STUDY OBJECTIVE The 2 antidotes for acute cyanide poisoning in the United States must be administered by intravenous injection. In the out-of-hospital setting, intravenous injection is not practical, particularly for mass casualties, and intramuscular injection would be preferred. The purpose of this study is to determine whether sodium nitrite and sodium thiosulfate are effective cyanide antid...

In normal conditions, nitric oxide (NO) is oxidized to the anion nitrite, but in hypoxia, this nitrite may be reduced back to NO by the nitrite reductase action of deoxygenated hemoglobin, acidic disproportionation, or xanthine oxidoreductase (XOR). Herein, is investigated the effects of topical sodium nitrite administration in a rat model of renal ischemia/reperfusion (I/R) injury. Rats were s...

In recent years, the use of nitrites and sulfites as food preservatives has been a cause for concern due to the health problems that these additives can cause in humans. Natural products have been studied as an alternative, but most of them have hardly been applied in the food industry for technological and economic reasons. In this sense, organic salts such as sodium acetate are a good alterna...

Insufficient nitric oxide (NO) bioavailability plays an important role in endothelial dysfunction and arterial stiffening with aging. Supplementation with sodium nitrite, a precursor of NO, ameliorates age-related vascular endothelial dysfunction and arterial stiffness in mice, but effects on humans, including the metabolic pathways altered, are unknown. The purpose of this study was to determi...