OBJECTIVE To evaluate changes of nuclear factor-kappa B (NF-κB) during radioiodine 131 ((131)I) therapy and whether NF-κB inhibition could enhance (131)I-induced apoptosis in differentiated thyroid cancer (DTC) cells in a synergistic manner. METHODS Three human DTC cell lines were used. NF-κB inhibition was achieved by using a NF-κB inhibitor (Bay 11-7082) or by p65 siRNA transfection. Methyl...

BACKGROUND The aim of the study was to achieve an effective target dose in the thyroid by increasing the effective half-life (Teff) of (131)I by use of iodide ((127)I) two days after (131)I therapy in patients with hyperthyroidism with low Teff. MATERIAL AND METHODS The study was carried out in two groups. Group A - 41 patients, and Group B - 14 patients, all the patients were with hyperthyro...

T was an eye-witness of the fruitful experiments conducted in the Headquarters Hospital of this district during 1924 by Lieut. E. A. Davies, t.m.d., and Assistant Surgeon Dr. P. Bell, r.M.D. (now Civil Surgeon). After taking over charge of this hospital I repeated these experiments on some patients of this subdivision and obtained good results. Unfortunately the Chins here do not consider goitr...

Rice rats were distributed by littermate into four experimental groups as follows: stannous fluoride (0.4%), iodine-sodium iodide (1.0%), a combination of iodine-sodium iodide and stannous fluoride, and a distilled water control. Each rat was treated by swabbing the molar teeth daily. All rats were fed diet 2000 and double-distilled water ad libitum, and were sacrificed after 9 weeks. Root surf...

The dehalogenation of a-haloketones and a-halocarbonyl compounds is an inevitable proce­ dure for the organic synthesis and these reductive dehalogenations have been often effected in organic syntheses. There have been various procedures for the purpose and these are obtained by zinc and acetic acid [1], sodium dithionite [2], titanium(III) chloride [3], organotin hydride [4], sodium hydrogen t...

An iodide ion-selective PVC membrane sensor based on copper (Π)-bis-Nphenilsalicyldenaminatocomplex as a novel sensing material is successfully developed. Theelectrode showed a good selectivity for iodide ion with respect to common inorganic anions. Thesensor exhibited a good linear response with slope of _58.6 ± 0.4 mV per decade over theconcentration range of 5.0 × 10-6 to 1.0 × 10-1 mol L-1,...

In total, 240 studies including serum T4, T3, TSH and thyroid uptake at 2 and 24 hrs were performed in 48 Bangladeshi adult individuals (52% female and 48% male). The aim of the present study was to make a correlation between thyroid serum levels and radioiodine thyroid uptake values of same individuals. Serum T4 and T3 were assessed with commercially available radioimmunoassay kits and TSH wit...

an iodide ion-selective pvc membrane sensor based on copper (π)-bis-nphenilsalicyldenaminatocomplex as a novel sensing material is successfully developed. theelectrode showed a good selectivity for iodide ion with respect to common inorganic anions. thesensor exhibited a good linear response with slope of _58.6 ± 0.4 mv per decade over theconcentration range of 5.0 × 10-6 to 1.0 × 10-1 mol l-1,...