pyknodysostosis is a rare bone disease characterzed with short stature,wide fontaneles,small chin,hyperdensity of bones,erosion of tufts of the disatl phalanges,and narrowing of the mandibular angle. pyknodysostosis is inheritted as an autosomal recessive disease and may be seen in both sexes at any age.the patients have normal life span.short stature and bone fractures are their major problems...

BACKGROUND AND PURPOSE Giant cell tumor (GCT) of the small bones (small-bone GCT) is usually rare and considered somewhat different from conventional GCT. The purpose of this study was to investigate and report the clinicopathological features of 11 cases with small-bone GCT. MATERIALS AND METHODS Patient information was obtained with the help of questionnaires. X-rays and paraffin blocks obt...

Bone fracture healing is a complex process including inflammation, repair and remodeling. Bone grafts or substitute are widely accepted to treat impaired healing. Newly developed bone substitutes must undergo in vitro and in vivo testing before clinical application. All kinds of intraosseous and heterotopic implant models in small and/ or large animals are used for different bone substitutes. O...

chondromyxoid fibroma is a rare benign cartilaginous neoplasm that mostly affects the metaphyseal region of the long bones. the tibia, small tubular bones of the foot, the distal femur and pelvis are common locations, but involvement of the vertebral bones, especially the cervical vertebra, is very rare. radiographic features show typical characteristics and this tumor often presents as a lobul...

results treatments through mirnas can prove to be beneficial due to its small size, easy synthesis, targeted and quick delivery. conclusions further work is needed to be done to make mirna treatments available to large number of people suffering from various bone diseases. context mirnas can regulate the expression of genes by interfering in their mrnas, acting as key regulators of diverse cell...

acute leukemia is the most common malignancy in childhood, which mainly involves children less than 15 years of age. the growing skeleton is the main site of involvement in children. leukemic cells proliferate within the massive red bone marrow in children. so besides the pallor, petechia, purpura and ecchymosis in the skin and mucosal surfaces, bone pain and other bony lesions are other manife...

Eight infants with radiographic and bone biopsy evidence of autosomal recessive osteopetrosis were evaluated by cranial CT. The clinical presentations and CT characteristics support the theory that this disorder exhibits severe and mild variants. At an early stage the severe variant demonstrates small optic canals, small orbits with proptosis, and a small nasoethmoid complex without significant...