نتایج جستجو برای: skmel
تعداد نتایج: 58 فیلتر نتایج به سال:
background and purpose: different methods such as surgery, chemotherapy, radiotherapy, hormone therapy and immunotherapy are used for treatment of melanoma cancer. unfortunately they don't always have desirable results and they may have unfavorable side effects. researchers try to find new, more effective drugs with low side effects. in this study we evaluated the cytotoxic effect of aca-1...
خیارهای دریایی متعلق به شاخه ی خارپوستان، کلاس holothuroidea هستند که گروه بزرگ و متنوعی از جانوران دریایی با حدود 1400 گونه در جهان را شامل می شوند. خیارهای دریایی از چندین منظر دارای اهمیت می باشند، از جمله: نقش اکولوژیکی آنها بدلیل تغییر در ترکیب کف دریا، اهمیت شیلاتی و آّبزی پروری آنها بدلیل ارزش خوراکی و تغذیه ای، اهمیت پزشکی-داروئی آنها بدلیل حضور ترکیباتی با اثر درمانی ضد باکتریایی، ضد قا...
Background and objectives: Dried pulps and peels of Ziziphus jujuba fruits are commonly applied as food because of their high nutritional value. It has been widely used in traditional medicine as laxative, tonic, wound healing agent and appetizer. The aim of this study was to evaluate the anti-melanogenic effects of Z. jujuba fruit. Methods: </st...
background and objectives: dried pulps and peels of ziziphus jujuba fruits are commonly applied as food because of their high nutritional value. it has been widely used in traditional medicine as laxative, tonic, wound healing agent and appetizer. the aim of this study was to evaluate the anti-melanogenic effects of z. jujuba fruit. methods: fruit extracts were obtained by two different extract...
The recent convergence of high-dimensional molecular datasets with small-molecule inhibitor pipelines allows for selective targeting of aberrantly regulated pathways in many cancer types. But intratumor heterogeneity, paradoxical activation, intrinsic or acquired therapeutic resistance, and non-linear pathway interactions confound most simple targeting strategies(Widmer et al., 2015). For insta...
We present a powerful experimental-computational technology for inferring network models that predict the response of cells to perturbations, and that may be useful in the design of combinatorial therapy against cancer. The experiments are systematic series of perturbations of cancer cell lines by targeted drugs, singly or in combination. The response to perturbation is quantified in terms of r...
The in vitro cytotoxicity, protein binding, partitioning of platinum from whole blood into erythrocytes, its exchange back into plasma, and the in vitro biotransformation in plasma were studied for the new nonnephrotoxic platinum analogue oxaliplatin. The cytotoxicity studies were carried out against a panel of human tumor cell lines derived from carcinomas of the ovary (A2780, A2780/cp), bladd...
Introduction In the second half of the 1970s, Lloyd J. Old and his group at Memorial Sloan-Kettering Cancer Center (MSKCC) discovered the first human cancer antigens by establishing an approach called “autologous typing.” The key preconditions of these discoveries were improvements in establishing human cancer cell lines from fresh tissue specimens and cultures from autologous healthy tissues, ...
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