In guinea pigs, when tubercufin sensitivity was passively transferred by lymphoid ceils sensitized to tubercle bacilli and labeled with tritiated thymidine, the transferred ceils were readily identified at the PPD skin test site (1). Further, the transfer of tuberculin sensitivity was not achieved by transferring BCG-sensitized cells enclosed in Millipore chambers (2). In mice, however, when tr...

To date, transplant arteriosclerosis (TA), the histologic counterpart of chronic transplant dysfunction, is the most important problem in clinical organ transplantation. Recently we showed in rats that intrathymic (IT) immune modulation substantially prolonged graft survival of MHC-incompatible, heterotopic vascularized cardiac allografts. Although acute rejection was prevented, eventually TA w...

Objective: This is an experimental study which aims at developing and evaluating the feasibility of experimental techniques of skin and vascularized abdominal heterotopic heart transplants in mice, creating an instrument of investigation for the effectiveness of preservation solutions, new immunosuppressive drugs, biological agents, genetic therapy and induction of immunological tolerance. Meth...

In kidney transplant patients, skin cancer is the most commonly involved neoplasm. More than 90% of post-transplantation skin cancers are nonmelanoma skin cancers (NMSCs). The majority of them are squamous cell carcinomas and basal cell carcinomas. Calcineurin inhibitors (CNIs) such as cyclosporine and tacrolimus are immunosuppressive agents given after solid organ transplantation, but they can...

Cancer stem cells have been described in various cancers including squamous tumours of the skin by their ability to reform secondary tumours upon transplantation into immunodeficient mice. Here, we used transplantation of limiting dilution of different populations of FACS-isolated tumour cells from four distinct mouse models of squamous skin tumours to investigate the frequency of tumour propag...

Organ transplant recipients are frequently affected by skin cancer, which might also be a major cause of long-term mortality. Excessive sun exposure is considered to be a factor in the aetiology, but uncertainty about the importance of this and other proposed risk factors remains. The purpose of this study was to investigate sun behaviour before and/or after the transplantation in kidney transp...

Bone marrow transfusion is a well-established method for induction of mixed hematopoietic chimerism and donor-specific tolerance in animal models. This procedure, however, is inapplicable in clinical transplantation using cadaveric donors due to the interval (1 week to 7 months) between tolerance induction and organ transplantation. For clinical use, it is essential that allografts be placed at...

Background: The higher frequency of malignant skin tumors is of great significance in renal transplant recipients (RTRs) who should receive immunosuppressive therapy for a long time. This study was designed to determine the frequency of malignant skin tumors in RTRs in Imam Reza Hospital, Mashhad, Iran, in 2001-2002.Method: This descriptive study was performed on 322 recipients who were examine...