OBJECTIVES Vector-borne diseases are still a major mortality factor in Africa and South-east Asia and effective mosquito repellents are therefore needed. An efficient and safe in-vitro assay system using artificial blood and skin substitute could facilitate the development of novel repellents, as most assays currently rely on human subjects or vertebrate whole blood. Moreover, examining the ski...

Full-thickness burns destroy both the epidermal and dermal tissues of the skin. This study evaluates a collagen and chondroitin-6-sulfate dermal skin substitute (graft) that was applied to excised full-thickness burns and covered with Biobrane. Experimental conditions included: (a) no burn, subcutaneous implantation of the graft; (b) burn, excision, graft, coverage with Biobrane and bandages; (...

This is an observational case series of 15 patients with full-thickness traumatic wound defects treated with a dermal substitute. There were 8 male and 7 female patients with a mean age of 36.6 years. Eight patients had trauma to the lower limbs and 7 were of the upper limbs, with the average lesion size 104.4 cm(2) (range 6-490 cm(2)). The time to complete healing had a mean average time of 26...

a substitute for collodion, but it never obtained the notice it deserved. Much more recently a similar preparation, having the attractive name of " New Skin," has been introduced and has a considerable reputation and sale. At my request, Messrs Duncan, Flockhart & Co. have prepared a solution of pyroxylin in acetic ether, to which they have given the provisional name of " Epicolloid." This has ...

In developing countries, such as Uganda, skin problems are among the most common ailments seen in primary healthcare settings (1). Due to the dire lack of trained dermatologists, the vast majority of patients with skin diseases in these countries are treated by substitute auxiliary health workers with a limited education in skin disease management (1). To bridge this gap in access to dermatolog...