Transdermal drug delivery systems of salbutamol sulphate using eudragit RL100 and PVP were developed by solvent casting technique employing mercury as a substrate. Propylene glycol was used as a plasticizer. The prepared films exhibited satisfactory physico-chemical characteristics. In vitro permeation profiles across the guinea-pig dorsal skin using K-C diffusion cell are reported. Incorporati...

formulation by using chemical penetration enhancers and to study the effect of pulsed current on permeation through guinea pig, Wistar rat and human cadaver skin. Modified Franz diffusion cell was used to study the in vitro permeation across various types of skin by iontophoresis. The thermo-reversible gel was prepared and optimized by cold method using poloxamer 407 as a gelling agent. Thermo-...

1. Abstract: The objective of this work was to develop suitable film formulations of ketorolac tromethamine (KT) for transdermal use and to investigate the effect of film composition and permeation enhancers on the in-vitro release and skin permeation of the drug. Polyvinyl alcohol (PVA), sodium carboxymethylcellulose (NaCMC), and chitosan were used as film-forming polymers. The adhesive hydrop...

Various electrolytes in test solutions applied to the skin were evaluated with regard to their effects on enhanced skin permeation of calcein as a model permeant by electroporation (EP), which is a physical means to increase skin penetration by applying a high voltage pulse on the skin surface. Calcein solution (1.0 mM) containing different electrolytes at a concentration of 150 mM was applied ...

The purpose of the present study was to develop a novel transdermal drug-delivery system comprising a polyamidoamine dendrimer coupled with sonophoresis to enhance the permeation of diclofenac (DF) through the skin. The novel transdermal drug-delivery system was developed by using a statistical Plackett-Burman design. Hairless male Wistar rat skin was used for the DF-permeation study. Coupling ...

The enhancing effect of ascorbic acid and triethyl citrate (TEC) on the in vitro skin permeation of rofecoxib across rat epidermis was investigated. Skin pre-treatment with ascorbic acid and TEC at different concentrations, followed by application of rofecoxib gel, showed higher permeation flux than the control condition. The mechanism underlying this permeation enhancement was probed with four...

The aim of the present study was to investigate the relationship between the polar surface area and other molecular properties of the model drugs and their transdermal permeability across the rat skin. Few model drugs which are weakly acidic (ibuprofen, aceclofenac and glipizide) and weakly basic (olanzapine, telmisartan and sildenafil citrate) were selected for the study based on Polar surface...

PURPOSE Classic penetration enhancement/retardation methods for improved dermal drug delivery primarily focus on co-applied chemicals aided alterations in skin accumulation/permeation profile, and in many cases, this has been achieved by compromising the systemic absorption/toxicities of penetrant/enhancer/retarder. In this study, higher dermal accumulation without systemic absorption of ketoro...

The aim of this study was to investigate the use of different types of microneedles (MNs) and nanocarriers for in vitro skin permeation and in vivo immunization of plasmid DNA encoding ovalbumin (pOVA). In vitro skin permeation studies indicated that hollow MNs had a superior enhancing effect on skin permeation compared with solid MN patches, electroporation (EP) patches, the combination of MN ...

In the present study, chitosan membranes capable of imitating permeation characteristics of diclofenac diethylamine across animal skin were prepared using cast drying method. The effect of concentration of chitosan, concentration of cross-linking agent (NaTPP), crosslinking time was studied using Taguchi design. Taguchi design ranked concentration of chitosan as the most important factor influe...