1. The maintenance of skeletal muscle mass is determined by a fine balance between protein synthesis and protein degradation. Skeletal mass is increased when there is a net gain in protein synthesis which can occur following progressive exercise training. In contrast, skeletal muscle mass is lost when degradation occurs more rapidly than synthesis and is observed in numerous conditions includin...

We investigated the change of body composition in ultra- endurance runners during a multi-stage ultra-endurance run, the Isarrun 2006 in Bavaria, Germany, where athletes had to run 338 km within 5 days. Body mass, skin fold thicknesses and circumferences of extremities were measured in 21 well-experienced extreme endurance male runners (mean ± SD, 41.5 ± 6.9 years, 72.6 ± 6.4 kg, 178 ± 5 cm, BM...

Skeletal muscle mass reflects a dynamic turnover between net protein synthesis and degradation. In addition, satellite cell inclusion may contribute to increase muscle mass while fiber loss results in a reduction of muscle mass. Since 2010, a few studies looked at the involvement of the newly discovered Hippo pathway in the regulation of muscle mass. In line with its roles in other organs, it h...

introduction: ursolic acid (ua) is a lipophilic triterpenoid compound, found in large amounts in apple peel. anabolic effects of ua on the skeletal muscle and the role of this tissue as a key regulator of systematic aging aroused this question in mind whether ua might amend skeletal muscle performances such as myoglobin expression and also whether it switches skeletal muscle fibers from glycoly...

Age-related loss of skeletal muscle mass and strength are risk factors for sarcopenia, osteoporosis, falls, fractures, frailty, and mortality. Dietary magnesium (Mg) could play a role in prevention of age-related loss of skeletal muscle mass, power, and strength directly through physiological mechanisms or indirectly through an impact on chronic low-grade inflammation, itself a risk factor for ...

Aging reduces skeletal muscle mass and strength, but the underlying molecular mechanisms remain elusive. Here, we used mouse models to investigate molecular mechanisms of age-related skeletal muscle weakness and atrophy as well as new potential interventions for these conditions. We identified two small molecules that significantly reduce age-related deficits in skeletal muscle strength, qualit...

The influence of cancer cachexia and chemotherapy and subsequent recovery of skeletal muscle protein mass and turnover was investigated in mice. Cancer cachexia was induced using colon 26 adenocarcinoma, which is characteristic of the human condition, and can be cured with 100% efficacy using an experimental nitrosourea, cystemustine (C(6)H(12)CIN(3)O(4)S). Reduced food intake was not a factor ...

Emelie Strandberg (2017): Skeletal Muscle Mass & Function in Older Women: Health-Enhancing Influences of Combined Resistance Exercise & Diet. Örebro Studies in Sport Sciences 26. Ageing is accompanied by a progressive decline in skeletal muscle mass and strength which may lead to impaired ability to perform activities of daily living in older adults. Although the exact cause of the gradual decl...

Skeletal muscle is essential for normal bodily function and the loss of skeletal muscle (i.e. muscle atrophy/wasting) can have a major impact on mobility, whole-body metabolism, disease resistance, and quality of life. Thus, there is a clear need for the development of therapies that can prevent the loss, or increase, of skeletal muscle mass. However, in order to develop such therapies, we will...