a single nucleotide polymorphism (snp) in cd24 has been associated with multiple sclerosis (ms) in a population based study. this snp results in the replacement of alanine (cd24a) by valine (cd24v) at amino acid 57 in the resulting polypeptide chain. in the current study, the genotyping of this snp and its contribution to ms in 217 patients and 200 healthy individuals of an iranian population w...

aim : leptin is a 16 kda polypeptide hormone which secreted by adipose tissue and has an important role in energy balance, insulin pathway and inflammation, because of that it may play an important role in colorectal cancer (crc). leptin exerts its effect through the leptin receptor (lepr) a member of the class i cytokine receptor family. background : we have investigated whether glutamine to a...

abstract background von willebrand disease (vwd) is an autosomally inherited bleeding disorder with the prevalence of 1% based on population studies. the disease phenotype is due to quantitative and structural/functional defects in von willebrand factor (vwf) which is a glycoprotein with essential role as a carrier of fviii in circulation and also it serves the function as hemostasis regulator....

A comparison of Arabidopsis DNA sequences revealed that the final nucleotides at the 3' end of approximately half of the Arabidopsis mRNAs, immediately upstream of the poly(A) tail, differ from the corresponding genomic sequences. This suggests that extra nucleotides were added to these mRNAs at their 3' termini prior to polyadenylation. Among the mRNAs containing additional nucleotides, approx...

urokinase might play a role in the formation of kidney stones. this study was done to determine the association between +4065 t/c polymorphism at the 3′-untranslated region of urokinase gene and calcium kidney stones. this case-control study was carried out on 70 cases with a history of calcium kidney stones and 70 controls from the baqiyatallah hospital of tehran in 2013. the study of polymorp...

conclusions lepr q223r polymorphisms may confer a significant risk of nafld and coronary atherosclerosis. the a allele in the k109r polymorphism might be considered an independent risk factor for coronary atherosclerosis in nafld patients. objectives to investigate the association of lepr polymorphisms at q223r and k109r with the risks of nafld and coronary atherosclerosis in the chinese han po...

Pre-messenger RNA (mRNA) 3'-end cleavage and subsequent polyadenylation strongly regulate gene expression. In comparison with the upstream or downstream motifs, relatively little is known about the feature differences of polyadenylation [poly(A)] sites among major kingdoms. We suspect that the precise poly(A) sites are very selective, and we therefore mapped mRNA poly(A) sites on complete and n...

We tested the ability of 87 profilin point mutations to complement temperature-sensitive and null mutations of the single profilin gene of the fission yeast Schizosaccharomyces pombe. We compared the biochemical properties of 13 stable noncomplementing profilins with an equal number of complementing profilin mutants. A large quantitative database revealed the following: 1) in a profilin null ba...

" One-step RNA pathogen detection with reverse transcriptase activity of a mutated thermostable Thermus aquaticus DNA polymerase. " EMBO through an abasic DNA lesion: structural basis for adenine selectivity. " A. " Mutant DNA polymerase for improved detection of single-nucleotide variations in microarrayed primer extension " Chem. Eur. A. " Increased single-nucleotide discrimination in allele-...

objective: plasmodium falciparum chloroquine resistance is a major problem in malaria endemic areas. single nucleotide polymorphisms in pfcrt and pfmdr1 genes are known to be associated with chloroquine resistance in some parts of the world. the major goal of the present study was to detect the five single nucleotide polymorphisms in pfmdr1 gene and one single nucleotide polymorphisms in pfcrt ...