Senior-Loken syndrome (SLS) is a rare autosomal recessive disease characterized by nephronophthisis and early-onset retinal degeneration. We used a large Iranian family with SLS to establish a molecular genetic diagnosis. Following clinical evaluation, we undertook homozygosity mapping in two affected family members and mutational analysis in known SLS genes coinciding with regions of homozygos...

The effects of magnesium stearate, sodium lauryl sulphate (SLS) and talc as lubricants on some powder and tablet properties of silicified microcrystalline cellulose (SMCC) were studied. Single and binary blends of talc, magnesium stearate and SLS at 1% concentration were evaluated as flow modulators on SMCC. Influence of the lubricants on the powder and tablet properties of metronidazole was al...

Paramagnetic NMR is a useful technique to study proteins and protein complexes and the use of paramagnetic relaxation enhancement (PRE) for this purpose has become wide-spread. PREs are commonly generated using paramagnetic spin labels (SLs) that contain an unpaired electron in the form of a nitroxide radical, with 1-oxyl-2,2,5,5-tetramethyl-2,5-dihydropyrrol-3-ylmethyl methane thiosulfonate (M...

Selective laser sintering (SLS) has been investigated for the production of bioactive implants and tissue scaffolds using composites of high-density polyethylene (HDPE) reinforced with hydroxyapatite (HA) with the aim of achieving the rapid manufacturing of customized implants. Single-layer and multilayer block specimens made of HA–HDPE composites with 30 and 40 vol % HA were sintered successfu...

PILATUS is a silicon hybrid pixel detector system, operating in single-photon-counting mode, that has been developed at the Paul Scherrer Institut for the needs of macromolecular crystallography at the Swiss Light Source (SLS). A calibrated PILATUS module has been characterized with monochromatic synchrotron radiation. The influence of charge sharing on the count rate and the overall energy res...

The multi-processor total tardiness problem (MPTTP) is an -hard scheduling problem, in which the goal is to minimise the tardiness of a set of jobs that are processed on a number of processors. Exact algorithms like branch and bound have proven to be impractical for the MPTTP, leaving stochastic local search (SLS) algorithms as the main alternative to find high-quality schedules. Among the avai...

Food contaminated with human pathogens, such as Salmonella spp. and Listeria monocytogenes, frequently causes outbreaks of foodborne illness. Consumer concern over the use of synthesized antimicrobials to enhance microbial food safety has led to a search of natural alternatives. The objectives of this study were to evaluate the antimicrobial activity of various types of sophorolipids (SLs) and ...

Sphingolipids (SLs) are compounds containing a long-chain fatty alcohol amine called sphingosine which exists in cellular membranes, cytoplasm, nucleus, interstitial fluid, blood and lymphatic circulation. SLs act as essential constituents of membranes of eukaryotic cells, so the seesaw of SLs will lead to structural alteration of membranes instigating cellular functional change. SLs also act a...

Two novel body/face wash gels enriched with emollient ingredients (including dexpanthenol) were developed for the daily care of dry skin. similarly designed 2-week studies (N = 42 each) conducted to assess biophysical and cosmetic performance each new in healthy adults Instrumental measurements quantified effects on stratum corneum (SC) hydration transepidermal water loss (TEWL) (with without a...

Modification of sodium lignosulfonate (SLS) via combined oxidationsulfomethylation was employed to prepare concrete superplasticizer. It was found that the oxidation of SLS by peroxyacetic acid facilitated the subsequent sulfomethylation. After modification, both the molecular weight and sulfo group content were significantly increased, and thus the performance of SLS as water reducer was impro...