the net analyte signal standard addition method was used for simultaneous spectrophotometric determination of sertraline and fluoxetine in pharmaceutical preparations. the method combines the advantages of the standard addition method with the net analyte signal concept to enable the extraction of information about an analyte from the spectra of multi-component mixtures. this method uses full s...

Brominated phenols (BPs), a widely used group of emerging flame retardants, are important environmental contaminants and exhibit endocrine disrupting potential. Method for simultaneous determination of tetrabromobisphenol A (TBBPA), tribromophenol (TBP), dibromophenols (DBPs) and monobromophenols (MBPs) in soils using gas chromatography-mass spectrometry analysis (GC/MS) was successfully develo...

This article discusses the determination of asymmetries. We consider a sample of events consisting of a peak of signal events on top of some background events. Both signal and background have an unknown asymmetry, e.g. a spin or forwardbackward asymmetry. A method is proposed which determines signal and background asymmetries simultaneously using event weighting. For vanishing asymmetries the s...

Three simple and sensitive methods were developed for the determination of a mixture of Rabeprazole sodium RB and Domperidone DP without prior separation. The first method A, isoabsorptive point comprised of measurement the total content of the mixture at their isoabsorptive point, while the content of RB was determined by measuring the first order derivative of its spectra at 231 nm, and the c...

A spectrophotometric method was developed for simultaneous determination of amlodipine (Aml) and valsartan (Val) without previous separation. In this method amlodipine in methanolic solution was determined using zero order UV spectrophotometry by measuring its absorbency at 360.5 nm without any interference from valsartan.Valsartan spectrum in zero order is totally overlapped with that of amlod...

trate, and Sulfate from Dried Urine Filter Paper Spots in a Pediatric Population, Nenad Blau, Ana Matasovic, Anna Lukasiewicz-Wedlechowicz, Claus W. Heizmann, and Ernst Leumann (Divisions of 1 Clinical Chemistry and Biochemistry and 2 Nephrology, University Children’s Hospital, Steinwiesstrasse 75, 8032 Zürich, Switzerland; * address for correspondence: University Children’s Hospital, Division ...

T HE POSSIBILITY OF DRUG intoxication frequently arises in patients admitted to the hospital in coma. Ingestion of salicylates by children and of barbiturates by adults are the most common causes. Since the introduction of glutethimide (2-ethyl-2-phenylglutarimide) in 1954, there have been increasing reports implicating this drug in drug intoxication. Since the clinical picture of glutethimide ...

Metallothionein (MT) has a dynamic role in cellular zinc metabolism. In order to determine the apoprotein thionein (T), an assay was developed. With this method tissue homogenates were treated with subtilisin to digest any T that might exist but MT could not be digested by subtilisin. MT was detected by cadmium-hemoglobin saturation method and T was determined as the difference of MT between sa...

Flow injection analysis (FIA) methods for the spectrophotometric determination of CO2 and SO2 in wines are described. The determination of CO2 is based on the colour change of a low capacity buffer (containing an acid-base indicator) due to the dissolved carbon dioxide. The determination of SO2 is based on the decoloration of malachite green by sulphur dioxide. Two FIA manifolds are presented; ...

second order advantage of excitation-emission fluorescence matrix was applied for the simultaneous determination of ibuprofen and caffeine. the proposed method is based on the measurement of the native fluorescence and recording emission spectra of ibuprofen and caffeine in different excitation wavelengths. the mixture of these compounds was resolved by multivariate curve resolution coupled wit...