BACKGROUND Bacteria produce small molecule iron chelators, known as siderophores, to facilitate the acquisition of iron from the environment. The synthesis of more than one siderophore and the production of multiple siderophore uptake systems by a single bacterial species are common place. The selective advantages conferred by the multiplicity of siderophore synthesis remains poorly understood....

Though iron is fourth in abundance in the earth crust it is not readily available to many m icroorga­ nisms: In the early days of earth life developed in a reductive atm osphere where iron necessary for many physiological processes was abundant in its divalent form. Fe2+-salts are sufficiently w ater soluble to provide an adequate supply of this elem ent to the cells. But as a consequence of th...

Siderophores are biogenic metallophores that can play significant roles in the dynamics of a range metals, including Cu, soil. Understanding impact siderophores on mobility and availability metals soil is required to optimize efficiency remediation processes such as phytoextraction. This study compared ability desferrioxamine B (DFOB) pyoverdine (Pvd) mobilize series Cu-contaminated soils, inve...

In microbial communities, bacteria chemically and physically interact with one another. Some of these interactions are mediated by secreted specialized metabolites that act as either intraspecies or interspecies signals to alter gene expression and to change cell physiology. Bacillus subtilis is a well-characterized soil microbe that can differentiate into multiple cell types, including metabol...

UNLABELLED Siderophores, small iron-binding molecules secreted by many microbial species, capture environmental iron for transport back into the cell. Vibrio cholerae synthesizes and uses the catechol siderophore vibriobactin and also uses siderophores secreted by other species, including enterobactin produced by Escherichia coli. E. coli secretes both canonical cyclic enterobactin and linear e...

Siderophores are a diverse group of low molecular weight biogenic metallophores with a particular affinity for Fe(III) but they also have potential to complex a number of other polyvalent metal cations, including Cr(III). Here we show that two hydroxamate siderophores, desferrioxamine B and rhodotorulic acid, at environmentally relevant concentrations, facilitate the dissolution of hydroxy-Cr(I...

Siderocalin (also lipocalin 2, NGAL or 24p3) binds iron as complexes with specific siderophores, which are low molecular weight, ferric ion-specific chelators. In innate immunity, siderocalin slows the growth of infecting bacteria by sequestering bacterial ferric siderophores. Siderocalin also binds simple catechols, which can serve as siderophores in the damaged urinary tract. Siderocalin has ...

Infections by drug-resistant bacteria are life-threatening. As iron is a vital element for the growth of bacteria, iron-chelating agents (siderophores) can be used to arrest their multiplication. Exogenous siderophores - exochelin-MS and deferoxamine-B - were evaluated for their inhibitory activity against methicillin-resistant Staphylococcus aureus and metallo-β-lactamase producers - Pseudomon...