SARCOIDOSIS is well recognized as a cause of swelling of the lacrimal glands and enters into the differential diagnosis of tumours of this region (DukeElder, 1952). Such swellings may be followed, in some cases, by a form of keratoconjunctivitis sicca (Ainslie and James, 1956; Gruber, 1956). The association of systemic sarcoidosis with keratoconjunctivitis sicca in the absence of swelling of th...

Background Salivary Gland ultrasound is a sensitive point of care investigation for the assessment salivary gland dysfunction. It can be abnormal in patients with primary Sjögren’s syndrome(pSS), Sarcoidosis, IgG4 disease, Systemic sclerosis, Infections and Tumors. Objectives To understand utility Anti-SSA, ANA Anti-SSA/SSB diagnosing Syndrome Sicca symptoms. Methods In current study, referred ...

Background Primary Sjögren’s Syndrome (pSS) is a chronic autoimmune syndrome characterised by sicca symptoms, fatigue, musculoskeletal pain and an increased risk of lymphoma. Patient populations are notably heterogeneous in their symptoms, adding to the challenge of pSS research. This study utilises serum samples from the UK Primary Sjögren’s Syndrome Registry (UKPSSR) a large cohort of clinica...

Chronic hepatitis C virus infection (CHCV) has high prevalence of immunological abnormalities. Extrahepatic manifestations (EHM) have been reported in association with CHCV infection, whose heterogeneity makes difficult any correlation between the two disorders. Among extrahepatic symptoms of C virus hepatitis, sicca syndrome is also registered. Sjögren's or sicca syndrome (SS) is a chronic, sl...

PURPOSE To evaluate the ocular presentation, treatment, and clinical course of graft-versus-host disease (GVHD). DESIGN Retrospective case series. PARTICIPANTS Two hundred and forty-nine patients with systemic GVHD were included in the study. METHODS Ocular and systemic data were collected from 2003 to 2013. MAIN OUTCOME MEASURES Mortality, visual acuity, and response of ocular symptoms...

Sjögren’s syndrome (SS) is a chronic autoimmune disease characterized by the lymphocytic infiltration of salivary and lacrymal glands leading to xerostomia and keratoconjunctivitis sicca (KCS). The prevalence of SS is variable but recent studies have estimated it to be between 0.1-0.6%(Goransson et al., 2011; Trontzas & Andrianakos, 2005). As such, SS occurs in middleaged patients with a high f...

Keratoconjunctivitis sicca, conjunctival scarring, fibrosis, metaplasia, and shrinkage developed in 27 patients as an adverse reaction to practolol. Rashes, nasal and mucosal ulceration, fibrous or plastic peritonitis, pleurisy, cochlear damage, and secretory otitis media also occurred in some cases. Three patients suffered profound visual loss though most retained good vision. Symptoms and sig...

Sicca features are the central clinical manifestations of Sjögren's syndrome (SS), but recent studies have confirmed that primary SS has a systemic expression, including extraglandular manifestations. Patients with a predominantly extraepithelial expression should be managed differently from patients with predominantly periepithelial or sicca limited disease. In coming years treatment will be b...