A 24-year old woman presented with hemorrhagic vesicles on her legs. She had taken sibutramine (Reductil®, Abbott Labs., Seoul, South Korea) for 3 months and developed skin lesions the week before. A skin biopsy showed leukocytoclastic vasculitis with conspicuous eosinophilic infiltration of the tissue. These lesions showed improvement after discontinuation of sibutramine. However, 3 months lat...

OBJECTIVE Our objective was to assess the efficacy and safety of sibutramine with a low-calorie diet (LCD) and commercial meal-replacement product in achieving weight loss and weight-loss maintenance in obese patients. RESEARCH METHODS AND PROCEDURES Eight U.S. centers recruited 148 obese patients for a 3-month comprehensive weight-loss therapy (Phase I) comprising daily sibutramine 10 mg + L...

OBJECTIVES Assess body mass index (BMI) reduction through a multidisciplinary intervention with sibutramine in adolescents of military parents and examine characteristics and behavioral traits as predictors of successful weight loss. METHODS A prospective study where participants received sibutramine daily for 6 months. Adolescents ages 12 to 18 with BMI-for-age and sex greater than 95 percen...

AIMS The Sibutramine Cardiovascular OUTcomes (SCOUT) trial is a randomized, double-blind comparison of sibutramine vs. placebo, in addition to standard care for weight management, in overweight/obese subjects with an increased risk of cardiovascular disease. The study had an initial single-blind, 6-week lead-in period with sibutramine plus weight management. We report the cardiovascular respons...

When the hypothalamic ventromedial nucleus and arcuate nucleus were destroyed in rats by treatment with monosodium glutamate in the neonatal stage, increase in the Lee index (body weight 1/3/body length) and in retroperitoneal fat as well as decreases in spontaneous motor activity, food consumption and growth hormone secretion function associated with hypothalamic low body length obesity (monos...

BACKGROUND AND AIM To investigate, through a meta-analysis of clinical trials, the effect of two weight-reducing drugs, such as orlistat and sibutramine, on serum lipid profiles in overweight and obese subjects, independently of weight loss. METHODS A systematic search strategy, incorporating the terms orlistat, sibutramine, fat, cholesterol, lipid profile, cardiovascular risk, was developed ...

UNLABELLED This is a double-blind, placebo-controlled study of the efficacy, safety, and tolerability of sibutramine in the management of obese patients for a 6-month period. METHOD Sixty-one obese patients (BMI >30, <40 kg/m2), aged 18-65 years were evaluated. In the first phase of the study (30 days), the patients were given a placebo. We monitored compliance with a low-calorie diet (1200 k...

Objective : аssessment of orlistat, liraglutide and sibutramine consumption in the Russian Federation as drugs recommended by clinical guidelines for pharmacotherapy obesity. Material methods. From IQVIA database, information was selected on retail sales procurement specified at expense federal regional budgets period 2011–2021. The consumed volumes each drug were recalculated into number defin...

Consumption of over-the-counter drugs or medicinal products in Turkey has been increasing following Turk-ish legislation on the classification of medicinal products in 2005, which regulates the marketing of over-the-counter drugs (Turkish Pharmacists' Association 2009). Moreover, many international pharmaceutical products are easily obtained via suppliers on the Internet (Mor-ris and Avorn 2003...

CONTEXT Systemic arterial hypertension is part of the metabolic syndrome resulting from obesity. OBJECTIVE To evaluate the effect of sibutramine on overweight and obese patients' blood pressure through a systematic review. METHODS All the studies included needed to be randomized controlled trials. The methodological quality of the selected trials was assessed using the criteria described in...