OBJECTIVE To investigate the effect of botulinum toxin type A (BTA) injection into the salivary gland and to evaluate the changes of drooling in varied postures in tetraplegic patients with brain injury. METHODS Eight tetraplegic patients with brain injury were enrolled. BTA was injected into each parotid and submandibular gland of both sides under ultrasonographic guidance. Drooling was meas...

Sialorrhea or excessive salivation, and drooling, are common and disabling manifestations in different neurological disorders. A review is made of the literature, based on a PubMed search, selecting those articles describing clinical trials involving the injection of botulinum toxin A in the salivary glands of patients with different diseases characterized by sialorrhea. The most frequently tre...

This study aims to determine the most efficacious dose of Botulinum neurotoxin type A (BoNT-A) in reducing sialorrhea in Asian adults with neurological diseases. A prospective, double-blind randomized controlled trial was conducted over 24 weeks. Thirty patients with significant sialorrhea were randomly assigned to receive a BoNT-A (Dysport(®)) injection into the submandibular and the parotid g...

PURPOSE Sialorrhea is the unintentional loss of saliva and other contents from the mouth. Most patients with this condition are elderly, requiring palliative treatment. These patients have neuropathology with associated poor performance status. Treatment prescribed for this disabling and distressing condition has often been of a surgical nature and described in young patients. It would be inapp...

OBJECTIVES/HYPOTHESIS Onabotulinum toxin A (OBTXA) injection is a well-established therapeutic option for the management of drooling. Many of the children treated undertake repeated injections every 3 to 6 months. We aimed to assess quantitative salivary gland changes via ultrasound imaging after intraglandular injection of OBTXA for sialorrhea treatment in children, as a method that suggests p...

AIM: To find out the knowledge attitude and practice of anti-sialagogue among dental students in chennai. BACKGROUND: The substances that decrease the production of saliva are called ANTISIALAGOGUE. Their effect is opposite to that of sialagogues. Sialogogue are the agents or drugs which are used to increase the salivation during dryness of mouth. AntiSialagogue may be natural or synthetic. The...

Antipsychotics are generally associated with dry mouth and deterioration of the oral health. However, clozapine, the archetype of the atypical antipsychotics, is reported to induce not only mouth dryness but also, in about one-third of the patients, hypersalivation, the latter resulting in disturbed sleep, coughing and choking sensations during the night and drooling during the day. Nevertheles...

Excessive drooling may complicate the care of children with chronic neurological conditions by socially isolating both patients and families and by causing secondary dermatitis and infection. Normal control of saliva requires normal integrity of oral structures, normal oropharyngeal sensation, and motor functioning, as well as normal cognitive awareness and rate of salivary production. Glycopyr...