In this article , the authors introduce a case of Caroli's Disease (CD) according to the results of ultrasonography (U.S), abdominal computed tomography (CT scan) and hepatic biopsy that has been manifested in the neonatal period. In the routine examination of the neonate, abdominal protrusion was noticed. Then milk intoterance, inability of meconium passage and vomiting developed, during w...

The membranous labyrinth of the inner ear, with its three semicircular canals, originates from a simple spheroidal otic vesicle. The process is easily observed in Xenopus. The vesicle develops three dorsal outpocketings; from the two opposite faces of each outpocketing pillars of tissue are protruded into the lumen; and these paired 'axial protrusions' eventually meet and fuse, to form a column...

Cellular protrusion formation capacity is a key feature of developing neurons and many eukaryotic cells. However, the mechanisms underlying membrane growth in protrusion formation are largely unclear. In this study, photo-reactive unnatural amino acid 3-(3-methyl-3H-diazirin-3-yl)-propamino-carbonyl-Nε-l-lysine was incorporated by a genetic code expansion strategy into protrudin, a protein loca...

The protrusion of filopodia and lamellipodia from the surface of neurons is fundamental to axon extension, guidance, the formation of axon branches, and synaptic structures. Protrusion is driven by the polymerization and controlled organization of actin filament arrays. This chapter provides an overview of the basic mechanisms operative during protrusion. Mechanisms underlying the suppression o...

BACKGROUND We present two patients who developed severe protrusion of the conjunctiva and chemosis secondary to Harlequin ichthyosis (HI). CASE REPORTS Case 1 was a male infant diagnosed with HI who had parchment-like appearance and conjunctival protrusion with severe chemosis. Case 2 was a female infant on whom HI had been suspected before birth through ultrasonography. She showed thickened ...

Protrusion formation is an essential step during cell migration. Cells migrating in three-dimensional environments and in vivo can form a wide variety of protrusion types, including actin polymerization-driven lamellipodia, and contractility-driven blebs. The ability to switch between different protrusions has been proposed to facilitate motility in complex environments and to promote cancer di...

We model the regulatory role of proteins bound to looped DNA using a simulation in which dsDNA is represented as a self-avoiding chain, and proteins as spherical protrusions. We simulate long self-avoiding chains using a sequential importance sampling Monte-Carlo algorithm, and compute the probabilities for chain looping with and without a protrusion. We find that a protrusion near one of the c...

Thick-walled X80 pipelines for oil and gas transportation are difficult to relocate due their large size. In the process of narrow-gap overhead welding, welding defects, such as bulges lack sidewall fusion, can appear easily. To avoid these defects improve quality thick-walled pipelines, GMAW method is adopted in this paper. The formation characteristics weld influence arc oscillation parameter...