OBJECTIVES The present study investigated the antidiabetic and hypolipidemic properties of Dorema aucheri leave hydroalcoholic extract in nicotinamide-streptozotocin induced type 2 diabetic rats. MATERIALS AND METHODS nicotinamide/streptozotocin-induced diabetic rats were supplemented orally with three different doses of D. aucheri (100, 200 and 400 mg/kg BW) or glibenclamide (0.25 mg/kg) for...

In 100 consecutive male inpatients with alcohol dependence and an equal number of age, sex, occupation and regional background matched controls, the value ofgamma-glutamyl transpeptidase (GGT), serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), mean corpuscular volume (MCV) and serum triglycerides were statistically significantly raised among alcoholics ...

The thiating effect of 1,3,2,4-dithiadiphosphitane2,4-bis(4-methoxyphenyl)-2,4-disulfide (1) on car­ bonyl compounds, leads to the formation of their thio-analogous [1—4], We have recently reported on the reaction of 1 with acetamides [5] and dicarbonyl compounds [6]. On the other hand, there are no compounds having o-diazo-thiono groups were re­ corded in the literature. Based on this findings...

Aim of the study was to evaluate the hepatoprotective activity of ethanolic seed extract of Lawsonia inermis against paracetamol induced liver damage in rats. Wistar albino rats of either sex were divided in to 5 groups of 6 each. The rats were intoxicated with paracetamol (750mg/kg) at every 72 hrs for 21 days. Silymarin (50mg/kg) and Lawsonia inermis (200 & 400 mg/kg) were orally administered...

Extract of Methanol:ethanol (70:30) of Prunus domestica was prepared and tested for its hepatoprotective effect against Paracetamol and CCl4 induced hepatitis in rats . Alteration in the levels of biochemical markers of hepatic damage like SGPT, SGOT, ALP,Total bilirubin, direct bilirubin and tissue LPO, GSH, catalase and SOD were tested in both treated and untreated groups. Paracetamol (2 g/kg...

The usefulness of blood enzyme determinations as markers of liver necrosis was tested in 100 alcoholics who underwent biopsy during clinical investigation. Mean values of glutamate dehydrogenase (GDH), serum aspartate and alanine transferase (SGOT and SGPT), ornithine carbamoyltransferase (OCT), and gamma-glutamyltranspeptidase (gamma-GTP) tended to rise with increasing liver cell necrosis, tho...

Study was undertaken to investigate the various oxidative stress markers and biochemical parameters in anxious rat. Rats were subjected for short (21 days) and long term (up to 84 days) social isolation; the rats displayed an increase in anxiety on elevated plus maze and open field test relative to control. Various markers of oxidative stress like lipid peroxidation (LPO), reduced glutathione (...