BACKGROUND This study was designed to clarify the significance of washout rate (WR) determined from 99mTc-sestamibi myocardial scintigraphic images and the levels of cardiac enzymes in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). MATERIAL/METHODS A total of 56 consecutive patients with AMI (mean age 65.8 ± 8.5 years), who underwent PCI on adm...

OBJECTIVES The aim of the study was to verify the prognostic implications of viability detection using baseline-nitrate sestamibi imaging in patients with left ventricular (LV) dysfunction due to chronic coronary artery disease (CAD) submitted to different therapeutic strategies. BACKGROUND The prognostic meaning of preserved viability in these patients is still debated. Sestamibi is increasing...

Aim of the present study was to investigate the feasibility and long-term results of focused radioguided parathyroidectomy using a "low" 37 MBq (1 mCi) 99mTc-sestamibi dose protocol compared to conventional "high 740 MBq (20 mCi) 99mTc-sestamibi dose protocol" in patients with primary hyperparathyroidism (PHPT). The data of focused radioguided surgery obtained in a group of 320 consecutive PHPT...

The multidrug-resistant P-glycoprotein (Pgp), a M(r) 170,000 plasma membrane protein encoded by the mammalian multidrug resistance gene (MDR1), appears to function as an energy-dependent efflux pump. Many of the drugs that interact with Pgp are lipophilic and cationic at physiological pH. We tested the hypothesis that the synthetic gamma-emitting organotechnetium complex, hexakis(2-methoxyisobu...

Wei, Kevin, Elizabeth Le, Jian-Ping Bin, Matthew Coggins, Ananda R. Jayawera, and Sanjiv Kaul. Mechanism of reversible Tc-sestamibi perfusion defects during pharmacologically induced vasodilatation. Am J Physiol Heart Circ Physiol 280: H1896–H1904, 2001.—Reversible perfusion defects on Tc-sestamibi imaging during hyperemia are thought to occur due to myocardial blood flow (MBF) “mismatch” betwe...

UNLABELLED Annexin A5 is a phospholipid binding protein with high affinity for phosphatidyl-serine, which is externalized by cells undergoing programmed cell death. An increased programmed cell death rate has been reported in the heart after myocardial infarction (MI). The aim of this study was to correctly localize annexin A5 uptake in vivo and to determine the area at risk in humans with acut...

Discussion | As illustrated by these cases, undescended parathyroid adenomas are challenging to identify with sestamibi studies. When sestamibi studies do not demonstrate uptake in the thyroid bed or mediastinum, careful scrutiny for asymmetry of the submandibular regions is warranted to rule out these lesions. Alternatively, 4-dimensional CT imaging is a useful adjunct for localizing undescend...

OBJECTIVES This work was undertaken to define the intrinsic cardiac risk of the patient population referred for dobutamine stress perfusion imaging and to determine whether dobutamine technetium-99m ((99m)Tc)-sestamibi single-photon emission computed tomography (SPECT) imaging is capable of risk stratification in this population. BACKGROUND In animal models, dobutamine attenuates the myocardi...

Detection of P-glycoprotein and other multidrug resistance protein activity is currently under investigation to identify subgroups of cancer patients with tumors resistant to chemotherapy. Application of a test that reliably evaluates the phenomenon in vivo would not only serve as a predictor for responses to chemotherapy but would also be of use in testing the efficacy of multidrug resistance ...

BACKGROUND Regional 201Tl activity after resting injection, imaged early and after redistribution, reflects viable myocardium and can predict improved isotope uptake as well as regional and global ventricular function after revascularization. 99mTc-sestamibi, a perfusion tracer with favorable imaging characteristics, has distinct kinetics compared with 201Tl, demonstrating minimal redistributio...