SUMMAR,Y Incubation of human serum solutions low in glyceride content for 16 hr resulted in a net increase of cholesterol esters in all three major human serum lipoprotein classes, namely the very low-density lipoproteins of d < 1.006 (VLDL), low-density lipoproteins of d 1.006-1.063 (LDL) and highdensity lipoproteins of d 1.063-1.21 (HDL). Transfer of glycerides from the VLDL to the LDL and HD...

We investigated the immunoprecipitation of apolipoprotein B-binding lipoproteins, or of apo A-I- and apo C-binding lipoproteins, by delipidated antiserum for measuring cholesterol in the nonprecipitated lipoprotein fractions. After immunoprecipitation of serum with delipidated anti-apo B, we determined by immunoelectrophoresis that no beta- or pre-beta lipoproteins were present, whereas alpha-l...

Schizophrenia is characterized by complex metabolic dysregulations and their consequences. Until now, numerous theories have explained its pathogenesis, using a spectrum of available technologies. We focused our interest on lipid profile—periphery high-density cholesterol level lipoproteins in the human brain compared magnetic resonance imaging (MRI) scans patients with schizophrenia healthy gr...

The alloxanized rabbit fed cholesterol develops extreme hyperlipemia and hypercholesteremla and yet develops a lesser degree of atherosclerosis than does the normal animal fed cholesterol. The concentrations of the Sf 12-30 and Sf 20-30 classes of lipoproteins correlate well with athero-sclerosis as finally observed in the alloxanized rabbit, whereas both free and total serum cholesterol correl...

Serum lipoproteins of pregnant and puerperal rats were studied by preparative and analytical ultracentrifugation. The concentration for the fraction with density less than 1.019 was markedly elevated in rats during the 3rd wk of gestation and in lactating rats. This fraction showed similar triglyceride fatty acid composition and immunoelectrophoretic behavior whether it was derived from pregnan...

Studies on the synovial fluid lipoproteins were initiated several years ago. In 1953 Ropes and Bauer (1) reported on the cholesterol content of joint fluid from patients with rheumatoid arthritis. Subsequently Schmid and MacNair (2, 3) noted that when referred to the same amount of protein rather than volume of fluid, the lipoprotein content of pathological and pooled postmortem synovial fluids...

SUMMAR,Y Incubation of human serum solutions low in glyceride content for 16 hr resulted in a net increase of cholesterol esters in all three major human serum lipoprotein classes, namely the very low-density lipoproteins of d < 1.006 (VLDL), low-density lipoproteins of d 1.006-1.063 (LDL) and highdensity lipoproteins of d 1.063-1.21 (HDL). Transfer of glycerides from the VLDL to the LDL and HD...

Lipoproteins of the Sf 12-100 class, representing only about 10 to 15 per cant of the serum cholesterol, are strongly associated with atherosclerosis. The major independent contributions to this association are from the Sf 12-20 lipoproteins and the Sf 35-100 lipoproteins. The Sf 20-35 lipoproteins are primarily associated by virtue of their intercorrelation with the other classes. Obesity is m...

After the administration of ccl4 to male rats, liver triglycerides began to increase after a lag period of about 1 hr; the level of serum triglycerides fell sharply during the first 30 min of intoxication. Three classes of serum lipoproteins were isolated by flotation in the ultracentrifuge and their concentrations and chemical compositions were determined. Within 4 hr of the administration of ...