Human serum albumin has been used as a model protein for protein folding and ligand binding studies over many decades. Due to its long life period and high concentration in plasma, HSA is highly sensitive to glycation. It is reported that 175 mg/dL glucose concentration is a threshold of kidney activity for the beginning of excretion of glucose. pH denaturation of HSA in absence and presence of...

sumac (rhus coriaria l.) is used as an herbal remedy in traditional medicine. the aim of this study was to determine the effects of sumac (rhus coriaria l.) on serum glycemic status, apolipoprotein (apo) b, apoa-i and total antioxidant capacity (tac) in type 2 diabetic patients. this double blind randomized controlled clinical trial was conducted on 41 type 2 diabetic volunteers randomly assign...

Objective: Stress and cortisol increase blood glucose. Considering the role of central catecholaminergic pathways on hypothalamic-pituitary adrenocortical axis, and results of some studies that alprazolam (a benzodiazepine) has inhibitory effect on catecholamines, it seems that alprazolam may reduce blood glucose. The aim of this study was to evaluate the effect of alprazolam on serum insulin l...

Background: Pomegranate seed oil and its main constituent, punicic acid, have been shown to decrease plasma glucose and have antioxidant activity. The objective of the present study was to examine the effects of pomegranate seed oil on rats with type 2 diabetes mellitus. Method: Six groups (n=8 each) of male Sprague-Dawley rats, comprising a control, a diabetic (induced by Streptozocin and Nico...

type 2 diabetes is a well-known endocrine and metabolic disorder which has reached epidemic proportions worldwide and represents a serious public health concern. hyperglycemia and dyslipidemia are two major abnormalities which are major cardiovascular risk factors. berberine is a major alkaloid in berberis vulgaris fruit extract (bvfe) which have important role in regulation of serum glucose an...

background hypovitaminosis d has been associated with the development of gestational diabetes mellitus (gdm) in many observational studies. objectives we report the first study of the impact of prenatal vitamin d supplementation on postpartum dysglycemia in gdm patients in a randomized clinical trial. patients and methods women with gdm at 12 - 32 weeks of gestation were assigned randomly to ei...

Strychnos henningsii Gilg is recommended among other remedies for the treatment of diabetes in traditional medicine of Southern Africa. The antidiabetic effect of oral administration of aqueous bark extract of the plant at 125, 250 and 500 mg/Kg body weight was investigated in diabetic rats induced with streptozotocin-nicotinamide for 15 days. The extract decreased the blood glucose level, feed...

Background: Urtica dioica has been used as antihypertensive, antihyperlipidemic and antidiabetic herbal medicine. The purpose of this study was to study the effect of hydroalcoholic extract of Urtica dioica on fructose-induced insulin resistance rats. Methods: Forty male Wistar rats were randomly divided into five groups including control, fructose, extract 50, extract 100 and extract 2...